September 26th 2024
Your daily dose of the clinical news you may have missed.
New Spin on Hypertension: Sequelae of Excess Glucocorticoids and Mineralocorticoids
August 28th 2012Persons with primary hyperaldosteronism and hypertension are at significantly increased risk for cardiovascular morbidity and mortality. But if these patients are treated with spironolactone and reach target blood pressure, their CV outcomes are the same as those of others with essential hypertension after 6.5 years of follow-up.
ß-Blockers for Hypertensives Without Other Comorbidities: Going, Going . . . Gone?
December 14th 2011During my residency in medicine, and for a generation after, ß-blockers were among first choices for lowering blood pressure. Now it seems that ß-blockers have evolved into disreputable antihypertensives. What’s changed over a generation?
Pulmonary Arteriovenous Malformation in a Woman With Severe Mitral Valve Stenosis
An 86-year-old woman presented with a 1-week history of worsening dyspnea, wheezing, and orthopnea. She denied chest pain, cough, or fever. She did not smoke cigarettes. Her oxygen saturation was 86% on 2 L/min via nasal cannula.
Gout, 2011: Q & A Update on an Ancient Scourge
October 22nd 2011Gout, once considered a disease of kings, is now a common and equal opportunity disease that affects as many as 3 million people in the US. Gouty arthritis has now become a serious problem in organ transplant recipients; in diuretic users; and in patients with CKD, hypertension, metabolic syndrome, heart failure, plus more.
Controlling Blood Pressure in Chronic Renal Disease: Nighttime Is the Right Time
October 14th 2011The authors’ opening salvo seems to say it all (again). . . “A patient’s nocturnal BP profile, without the pressor effect of physical activity, emotional stress, and environmental factors that are usually present during the day, is more representative of the true BP status and a stronger predictor of cardiovascular outcomes.”
A Man With Transient Dyspnea After Taking Tadalafil
August 31st 2011A 26-year-old man presented with sudden onset of palpitations and shortness of breath after incidentally taking tadalafil. He had no other symptoms and no history of illnesses during childhood. He drank socially but denied smoking and use of illicit drugs.
Pseudo-MI in a Patient with Pancreatitis and Polyarteritis Nodosa
August 30th 2011A 38-year-old man with a history of alcoholism, intravenous drug use, and cerebrovascular accident was referred for assessment of possible endocarditis, based on history, fever 39 °C (102.9 °F) and mildly elevated troponin level.
NSAIDs: Prescribing Grows Even More Complex
August 25th 2011For years, GI toxicity and risk of bleeding were the issues of most concern when deciding to prescribe an NSAID. The cardiac effects associated with these drugs were considered a positive in that least some have been shown to provide prophylaxis against myocardial infarction.
After Metformin, Antihyperglycemic Choices a Judgment Call
May 11th 2011A review of 140 trials and 26 observational studies supports metformin as the best first-line treatment for type 2 diabetes in adults, both stand-alone and in combination with other medications. But second-line treatments are still a judgment call.
Regular Exercise in Middle Age Can Build Heart Muscle
April 8th 2011Exercising at least 4 times a week can increase left ventricular mass and preserve elasticity, thereby reducing the risk of diastolic heart failure. Researchers from Texas presented their study results at the American College of Cardiology’s 60th Annual Scientific Session.
Chronic Heart Failure Outcomes Not Improved by NT-proBNP-Guided Treatment
April 6th 2011A Danish study found no clinical benefit from using NT-proBNP (b-type natriuretic peptide) to identify and monitor high-risk patients with chronic heart failure, according to research from the NorthStar study presented at the American College of Cardiology’s 60th Annual Scientific Session in New Orleans.