Direct Mail to Older Adults at Risk for Pneumococcal Disease Improves Vaccination Rates
A mail campaign targeting adults with chronic conditions as well as their GPs increased the number receiving at least 1 shot by 9.5 percentage points.
The Toll of Atopic Dermatitis is More than Skin Deep: Q & A with Harvard Child Psychologist Jennifer LeBovidge, PhD
Awareness of the psychological burden of eczema is improving, LeBovidge says, but if clinicians don't address mental health, patients and families will suffer in silence.
Low-Dose Colchicine 0.5 mg Reduced Total Plaque Volume in Stable CAD vs Placebo
Findings of the EXSTROM trial may help elucidate the mechanism by which low-dose colchicine prevents MI and stroke in adults with established CAD, experts suggest.
Methylone (TSND-201) for PTSD Shows Rapid, Sustained Symptom Improvement in Phase 2 IMPACT-1 Trial
In treatment-resistant PTSD, TSND-201 was associated with statistically significant symptom improvement as early as day 10 in the phase 2 IMPACT-1 trial.
Oral Semaglutide Lowers Risk of MACE 14% in High-Risk Adults: Final Phase 3 SOUL Trial Readout
ACC.25. The results seen with the only oral GLP-1 mimetic reflect "a profound clinical impact" for adults at high risk for MACE who are averse to injectable therapy.
Lepodisiran Reduced Lp(a) Levels by Nearly 94% in Phase 2 ALPACA Trial, Slated for Phase 3 Development
Lepodisiran at 400 mg maintained reductions of Lp(a), an inherited risk factor for cardiovascular disease, at ~90% at 1 year and ~75% at 1.5 years, Eli Lilly reported.
Dupilumab is Safe and Effective Across Pediatric Populations with Severe Atopic Dermatitis: New Meta-Analysis
Dupilumab significantly improved measures of severe AD, including EASI and IGA, as well as pruritis in pediatric populations aged 6 months to 18 years vs placebo.
Pediatric Fentanyl Poisonings Spiral Up 1,200% Over 8 Years, Study Finds
In the pediatric population aged 0 to 19 years, exposure to fentanyl was through intentional use by two-thirds, investigators found.
Measles is Dangerous in Adults: Who and How to Assess for the MMR Booster
The 2025 measles outbreak is predominantly affecting children, but measles is highly contagious and adults remain at risk, especially if they have not received the MMR vaccination.
Lilly Expands Digital Health Platform to Address Critical Gaps in Alzheimer's Disease Diagnosis and Care
An estimated 3000 Americans progress daily from mild to moderate or severe stages of Alzheimer's disease, making timely diagnosis imperative, Lilly said.
Omnipod 5 System Leads to Significant Glycemic Improvements After Direct Transition from MDI Insulin with CGM
Mean reduction in HbA1c was nearly 1% after transition from MDI plus CGM to Omnipod 5 in the first randomized trial to evaluate the shift in mode of insulin delivery.
For Sleep Disturbance in Alzheimer Disease, Cannabinoid-Based IGC-AD1 Shines in Phase 2
Depression, Anxiety Underrecognized and Undertreated in COPD, Increasing Disease Burden
A new analysis reveals significant gaps in diagnosis of and treatment for psychiatric disorders in adults with COPD and calls for larger, longitudinal studies.
UK Research Collaborative Will Evaluate GSK Shingles Vaccine Effect on Dementia
GSK is partnering with the UK Dementia Research Institute and Health Data Research UK to further investigate the potential for the RZV vaccine to mitigate cognitive decline.
Viking Therapeutics Completes Enrollment for Phase 2 Trial of Oral Obesity Tablet
Data from the phase 2 VENTURE-Oral Dosing Trial of VK2735 is expected in the second half of the year, the company said.
Eisai Will Highlight Real-World Experience Data with Lecanemab at 2025 American Academy of Neurology Meeting
Data on use of lecanemab in real world clinical settings will come from a neurologic case series review and a retrospective chart review of long-term use, both in early AD.
Nearly Half of Adults Diagnosed with MDD May Have Treatment Resistant Depression, Many Feel Hopeless
More than one-third of study participants with TRD had failed to get relief from 4 or more antidepressants, calling treatment experiences a "trial and error" process.
Does it Itch? Is it Painful? Is it Dry? Dermatoses Symptoms Don't Lie
Raj Chovatiya, MD, PhD, MSCI, actually said symptoms "never" lie so, particularly in patients with skin of color, if skin signs aren't clear, ask about the patient's experience.
More Evidence that Women Face Greater CVD Risk than Men, Even When Baseline Health is Equal
For the same level of baseline health, the increase in risk related to each of 8 key CV risk factors appears significantly higher in women than in men.
Initial Treatment with Dual Statin + Ezetimibe Cuts All-Cause Mortality by 50%: New Meta-Analysis
The reductions observed in all-cause mortality (49%) and MACE (39%) in high-risk patients compared with statin monotherapy could be practice changing, researchers said.
Does Skin Tone Affect Efficacy of Therapy for Atopic Dermatitis? Probably Not
AAD 2025: Raj Chovatiya, MD, PhD, MSCI, well-known physician scientist, says underrepresentation in clinical trials of those with skin of color precludes an evidence-based answer.
Early Amyloid Plaque Removal May Delay Alzheimer Disease Onset, A First-of-Its-Kind Study Suggests
In a small study of adults genetically predisposed to early-onset dementia, anti-amyloid treatment to remove plaque reduced risk of developing symptoms by 50%.
The 10 States with the Highest Risk for Cancer
The greatest risk for developing cancer faces residents of South Dakota, where radon levels are the nation's highest, and ranks for alcohol consumption and obesity are poor.
Guselkumab (Tremfya) Wins Approval for Crohn Disease, Fourth Indication for Immune-Mediated Diseases
The IL-23 inhibitor is the only drug in the class available with both subcutaneous and intravenous administration options for treatment induction, according to J&J.
The Exposome is Everything in Atopic Dermatitis: An Expert Perspective on AD Pathophysiology
Raj Chovatiya, MD, PhD, MSCI, discusses the complex and widely variable influences that affect the manifestations and burden of atopic dermatitis across populations.
Melanin Isn't Everything: Skin Physiology Does Not Conform to Socially Defined Variables, Explains Raj Chovatiya, MD, PhD, MSCI
AAD 2025: Chovatiya discusses whether melanin concentration plays a role in skin physiology and cautioned against typing with factors that are not true biologic constructs.
In Patients with Skin of Color, Lebrikizumab for Atopic Dermatitis Gets High Marks for Treatment Satisfaction
In individuals with skin of color with AD, lebrikizumab was associated with improved QoL and importantly with high rates of patient-reported treatment satisfaction.
ZUPREME-1 Phase 2b Trial of Petrelentide for Obesity Completes Enrollment
The amylin analog at 5 doses will be compared with placebo when added to a reduced calorie diet and increased physical activity regimen for 42 weeks, said Zealand Pharma.
What We Mean When We Say "Skin of Color" in Dermatology: A Closer Look with Raj Chovatiya, MD, PhD, MSCI
Chovatiya, expert clinical dermatologist and researcher, points out that the term "skin of color" comprises a heterogenous set of topics, in an interview at AAD 2025.
Antibiotics, NSAIDs Reported Most Common Cause of Pediatric Anaphylaxis
Among pediatric patients aged 1 month to 18 years with emergent anaphylaxis, cephalosporins were the leading antibiotics and ibuprofen the top NSAID implicated in a new study.