Testosterone Replacement Does Not Increase Risk for CV Events in Men with Hypogonadism, New Study Finds
ENDO 2023. In older men with hypogonadism and CVD, there was no difference in incident CVD between those taking testosterone and those taking placebo.
Friday's 5 Quotes for Primary Care 6-19-2023
Ozempic impact on patients, clinicians; bempedoic acid comparable to statins; hypertension risk upped with oral estrogen HT; and 2 more quotes of note.
Bempedoic Acid Found Comparable to Statins for Lowering LDL-C, Reducing Major CV Event Risk
ENDO 2023: Treatment with bempedoic acid was found comparable to statin therapy in an analysis of the CLEAR Outcomes trial based on CTT Collaboration methodology.
Early Time-restricted Feeding Regimen Improves Glycemic Variability, Time in Range in Patients with Prediabetes, Obesity
ENDO 2023. The pattern of intermittent fasting improved glycemic measures in a weight-independent fashion after just 7 days, according to the study abstract.
AMA Urges Clinicians to De-emphasize Use of BMI to Gauge Health, Obesity
Acknowledging the historical harm caused by sole reliance on the measure for decisions in clinical practice, the AMA urges clinicians to incorporate other valid measures.
Monovalent Vaccine Against SARS-CoV-2 XBB Lineage Leads June 15 VRBPAC Meeting Agenda
The FDA advisory committee will review all current surveillance data and recommend which strain/s to include in updated COVID-19 vaccines for the 2023-2024 vaccination campaign.
Risk of Hypertension in Postmenopausal Women Higher with Oral Estrogen-only Hormone Therapy
Oral estrogen hormone therapy was more likely to result in incident hypertension than transdermal or vaginal formulations in this large prospective population-based study.
Elevated Lp(a) Levels Found Independent Predictors of Recurrent CHD in Australian Cohort
Increased levels of lipoprotein(a) significantly and independently predicted recurrent CHD events in adults aged 60 years and older, report study authors.
Flash CGM Improves Time in Range, HbA1c in Patients with T2D Using Noninsulin Therapies
Mean time in range increased by ~10% and time above range decreased by 8.1% in study participants taking as few as a single antihyperglycemic medication.
Friday's 5 Quotes for Primary Care 6-9-2023
FDA fast tracks triple-threat antithrombotic, dangers of faux semaglutide online, a guide to neurologic sequelae of COVID-19, plus 2 more reviews of note.
10 Questions on Holiday Alcohol Habits in the US
July 4th invites celebration, typically with alcohol. Try our quiz based on a review of the holiday drinking patterns of US adults. Are answers to these 10 questions what you expect?
CGM Uptake for T2D in Primary Care and Endocrinology: Rates, Correlates, Considerations
Prescriptions for continuous glucose monitoring for patients with T2D are increasing, a new study finds, and the authors report on characteristics of new CGM users.
SGLT-2 Inhibitors Linked to Reduced Risk for Wide Range of Cancers in Study from Taiwan
Reduced risk for 10 different cancers was reported among patients with diabetes treated with SGLT2 inhibitors compared with those not treated.
How to Identify Neurologic Symptoms of Long COVID in a Short Primary Care Visit: A Physiatry-based Guide
Primary care clinicians will often be the first challenged to recognize neurologic sequelae of COVID-19; here's how to maximize short visits to assess long COVID.
FDA Posts Warning on Compounded Semaglutide Products, Citing Reports of Adverse Events
Compounded versions of semaglutide, often sold online, may contain salt versions of the molecule and are not evaluated by the FDA for safety or efficacy.
The Long COVID Neuro Differential Dx: Sometimes Tricky, Always Nuanced
Coauthor of a new multidisciplinary guidance statement on assessment of neurologic sequelae of long COVID highlights a consensus on steps to rule the condition out.
Long COVID Typically Presents in Symptom Clusters, Rarely as a Single Complaint, Expert Explains
A Feinberg School of Medicine physiatrist with long experience assessing long COVID talks specifically about common neurologic sequelae of the infection.
Friday's 5 Quotes for Primary Care 6-2-2023
The world's first RSV vaccine and the virus surveillance that is missing, PCPs missing opportunities to treat obesity, T2D linked to subclinical CVD, and more news.
Pfizer Wins FDA Approval for Vaccine against RSV in Older Adults
The FDA's decision was based on data from the pivotal phase 3 RENOIR trial, which demonstrated the efficacy, immunogenicity, and safety of Abrysvo in adults aged ≥60 years.
Long COVID was Apparent by Summer 2020 and in a Wide Range of Patients
Symptoms of long COVID were apparent by the summer of 2020, said physiatrist Dr Leslie Rydberg, coauthor of new consensus guidelines on management of neurologic sequelae.
One in 3 US Adults with T2D Shows Evidence of Subclinical CVD Based on Cardiac Biomarkers
As indicated by levels of 2 common biomarkers of cardiac injury, 33.4% of US adults with T2D showed evidence of undetected CVD vs only 16.1% of those without T2D.
FDA Approves SGLT-2/1 Inhibitor Sotagliflozin, Grants Broad Heart Failure Indication
The novel co-inhibitor of sodium glucose cotransporter-1/2 proteins will be available by the end of June 2023, according to Lexicon Pharmaceuticals.
Robust RSV Surveillance Data Will be Key to Getting US Clinicians Comfortable with New Adult Vaccine
Immunize.org's Dr Kelly Moore says that without clear surveillance data on RSV, particularly on hospitalizations, clinicians may hesitate to commit office resources to administration.
Are US Seniors Ready for an RSV Vaccine? Consider the Lessons of COVID-19, says Dr Kelly Moore
Low awareness of RSV in adults and misperceptions about the goal of vaccination aren't new challenges, says Kelly Moore, MD, MPH, Immunize.org president and CEO.
FDA Approves Rx Nalmefene Nasal Spray to Reverse Opioid Overdose
In a unique pharmacodynamic study, nalmefene demonstrated rapid reversal of respiratory depression from the synthetic opioid remifentanil and sustained duration of action.
Weight Loss of 15% with Oral Semaglutide 50 mg Equal to SQ Wegovy: Late Stage Clinical Trial
Efficacy of the daily pill met the standard now established by the once-weekly injection of 15% loss of baseline bodyweight in adults with overweight or obesity, says Novo Nordisk.
Migraine without Aura May Increase Stroke Risk for Women Taking Combined Hormonal Contraceptives
The findings contradict published clinical guidelines that warn against use of estrogen-containing birth control by women who have migraine with aura.
GSK Adult RSV Vaxx: Public Health Expert Reviews Topics for ACIP Meeting in June
Immunize.org president and CEO Kelly Moore, MD, MHP, describes the holistic view the ACIP will take of the virus, the vaccine, and the overall economics of the immunization.
Statin Therapy May be Protective Against Stroke in People with Atrial Fibrillation: New Study
Statin therapy initiated within 1 year of diagnosis of atrial fibrillation reduced the risk of ischemic stroke or systemic embolism by nearly 20%.
FDA Advisory Group Votes in Favor of Pfizer Investigational Maternal RSV Vaccine Candidate
The Pfizer vaccine RSVpreF administered to pregnant people was judged by the advisory committee to be effective at preventing RSV in infants from birth to 6 months.