PAD Risk Amplifiers and Screening Strategies: A Talk with Foluso Fakorede, MD
ACP 2025: Dr Fakorede outlines PAD risk amplifiers, polyvascular disease connections, and when to screen using ABI, TBI, or exercise testing in high-risk patients.
AstraZeneca's Triple Inhaled Therapy Meets Primary Endpoints in Phase 3 Trials of Uncontrolled Asthma
The KALOS and LOGOS registration trials in patients with uncontrolled asthma compared the triple fixed dose BGF with dual combination therapy.
Adolescent Hyperglycemia, Insulin Resistance Drive Early Cardiac Structural Changes, Novel Cohort Study Finds
Persistent hyperglycemia between ages 17 and 24 tripled the risk of left ventricular hypertrophy and did so 5 times faster among young women, a new study found.
Peripheral Artery Disease in Primary Care: Expert Insights on Recognition & Risk Factors
ACP 2025: Foluso Fakorede, MD, discusses the importance of recognizing and screening for peripheral artery disease in primary care.
FDA Approves STS101 (Dihydroergotamine) Nasal Powder for Acute Treatment of Migraine
The only approved DHE nasal powder addresses persistent limitations of existing DHE formulations, including liquid nasal sprays and injectables, Satsuma stated.
Mepolizumab Reduces AER in COPD Leading to Emergency Care by 35%: MATINEE Findings Published in NEJM
Mepolizumab also cut annualized exacerbation rates by 21% across the full study cohort and by 31% in a subgroup of participants with chronic bronchitis only.
Burden of Moderate to Severe Atopic Dermatitis Weighs Heavily on Children and Adolescents: Real-World Analysis
The burden of disease was particularly pronounced among adolescents, including significantly greater impact on quality of life and psychosocial interaction.
Signs of Alzheimer Disease vs Age-Related Changes
Occasional trouble finding a word reflect typical age-related brain changes; the changes that cause a person to refer to a watch as a "hand clock" are not.
High Blood Pressure Advisory in EHR Improves Hypertension Diagnosis, Control Across a Primary Care Network
An EHR advisory that combined alerts to medical assistants with escalation to clinicians increased likelihood of hypertension control by a mean 18% per month.
Loneliness Poses a Critical Barrier to Chronic Care Management
A new survey found that the loneliness linked to a diagnosis of chronic illness saps motivation to seek regular care and almost universally to take medications as prescribed.
Alzheimer Disease in 2025: American Perspectives
US adults want to know if they have Alzheimer disease and early, when treatment may slow it down; they are even willing to risk participation in trials of new drugs. Read more.
Amyloid and Tau Biomarkers of Alzheimer Disease Found in Individuals with Other Dementias
Biomarkers in a pattern characteristic of Alzheimer pathology were identified in unspecified dementia, Parkinson dementia, and frontotemporal dementia.
Switching Anti-CGRP Monoclonal Antibody Therapy in Nonresponders with Migraine May Reduce Monthly Headache Days
Subgroup analyses found no significant difference in efficacy based on change in therapeutic action (ie, CGRP vs its receptor), doses, or intertreatment interval.
AI Detects Nearly One-Third of Breast Cancers Previously Undetected by Radiologists on DBT Imaging
The AI program also correctly identified 90% of true positive cases, according to new data presented at the Society for Breast Imaging's annual symposium.
Metabolic Syndrome Linked to Risk of Young Onset Dementia
Authors found a dose-response relationship between MetS and dementia onset in the 4th decade; in those with all 5 components, risk of dementia was increased by 77%.
Endemic Measles is a Clear and Present Danger, According to Stanford University Modeling Study
At current vaccination rates, measles could become endemic in the US again within 21 years; the threat extends to rubella, polio, and diphtheria, the study found.
Postpartum Hormonal Contraceptive Use Linked to Increased Risk of Depression
The increased risk of depression when oral contraceptives were started following childbirth was "instantaneous," researchers wrote, and was ~50% greater than nonuse.
Precision Obesity Medicine Breakthroughs To Lead DDW 2025 Presentations from Phenomix Sciences
Phenomix will showcase new data on prediction of adverse events to GLP-1 RA therapy, a new obesity sub-phenotype, and approaches to improve surgical outcomes.
The Role for CGM in Glycemic Management Will Continue to Expand, Including in Prediabetes, Expert Says
CGM is now standard of care in T1D and evidence is solid for a role in insulin-treated T2D; Thomas Martens, MD, shares thoughts on CGM growth in the next 3-5 years.
How to Maximize CGM Data Presented in the Ambulatory Glucose Profile: Thomas Martens, MD, Illustrates
Martens, medical director of the International Diabetes Center (IDC) in Minneapolis, highlights an IDC resource that helps target problem areas in management of hyperglycemia.
Smoking Rates Hit New Low, But Cervical Cancer Screening Still Lags: 2025 ACS Report
While smoking in the US continues to decline, the American Cancer Society reports mixed progress in major cancer risk factors, prevention, and screening.
False Beliefs about MMR Vaccine, Measles Reach the Majority of US Adults: KFF Poll on Health Information & Trust
Misinformation about measles and the MMR vaccine has reached the majority of US adults and parents; most believe the vaccine is safe but many are still unconvinced.
GRAIL to Share Real-World Data from 100,000 Galleri Multi-Cancer Detection Tests at 2025 AACR Meeting
GRAIL announced plans to present new support for the Galleri test's ability to simultaneously screen for multiple cancers plus its accuracy for cancer signal of origin prediction.
Intermittent and Continuous Glucose Monitoring: Thomas Martens, MD, Details the Differences
Martens, Director of the International Diabetes Center, in Minneapolis, highlights the differences between the 2 methods and what the research has found on each.
Suicide Prevention in Primary Care: A Family Physician on Screening, Risk, and Follow-Up
Suicide prevention falls squarely in the purview of primary care practitioners, says family physician Teresa Lovins, MD. She reviews an intervention with remarkable results.
Early Menopause Was Associated with Increased Risk of Cognitive Decline, Depression within 2 Years
The findings suggest that women who experience early menopause (age <40 vs >50 years) may constitute a sex-specific high-risk group for cognitive decline.
One in Three Cases of Dementia May be Attributable to Hearing Loss: Population-Based Study
Interventions to protect or improve auditory health across the lifespan could be a cost-effective means of slowing the rapid rise of dementia in the US, authors wrote.
The Rich and Robust Data from CGM You Just Can't Get from Finger Sticks: A Talk with Thomas Martens, MD
Global Burden of Atopic Dermatitis in Older Adults Underestimated and Expected to Rise Substantially by 2050
The global prevalence of AD in older adults increased by 107% between 1990 and 2021, with a greater burden among women and in high sociodemographic regions.
Smart Ring Outperforms Apple Watch for Atrial Fibrillation Detection
The CART ring was superior to the Apple Watch in automated AF detection with fewer unclassified ECGs, but neither device should serve as a definitive diagnostic tool.