Fecal Microbiota Treatment via Colonoscopy Safe, Effective for Recurrent C. Diff, Study Suggests
DDW 2025. Colonoscopic delivery of fecal therapy prevented recurrent C. diff infection in 95% of participants for 8 weeks, with mild GI adverse events reported by <10%.
BD Onclarity Added to ASCCP Guidelines: What It Means
An interview with Jeff Andrews, MD, FRCSC, of BD Life Sciences.
Multitarget Stool DNA Testing Outperforms FIT/FOBT for Completed Follow-up Colonoscopy in CRC-Vulnerable Populations
DDW 2025. Follow-up colonoscopy after a positive stool-based test was superior among adults aged 45-49 and across diverse populations whose original test was mt-sDNA.
Marschall Runge, MD PhD, Shares Thoughts on the Trajectory of Measles in the US
Measles, declared eradicated in the US 25years ago, has infected 900 Americans and is responsible for 3 deaths of children younger than age 5. How did we get here?
PAD Risk Amplifiers and Screening Strategies: A Talk with Foluso Fakorede, MD
ACP 2025: Dr Fakorede outlines PAD risk amplifiers, polyvascular disease connections, and when to screen using ABI, TBI, or exercise testing in high-risk patients.
AstraZeneca's Triple Inhaled Therapy Meets Primary Endpoints in Phase 3 Trials of Uncontrolled Asthma
The KALOS and LOGOS registration trials in patients with uncontrolled asthma compared the triple fixed dose BGF with dual combination therapy.
The Role of Extended HPV Genotyping In Managing High Risk Patients
Adolescent Hyperglycemia, Insulin Resistance Drive Early Cardiac Structural Changes, Novel Cohort Study Finds
Persistent hyperglycemia between ages 17 and 24 tripled the risk of left ventricular hypertrophy and did so 5 times faster among young women, a new study found.
Direct Mail to Older Adults at Risk for Pneumococcal Disease Improves Vaccination Rates
A mail campaign targeting adults with chronic conditions as well as their GPs increased the number receiving at least 1 shot by 9.5 percentage points.
Peripheral Artery Disease in Primary Care: Expert Insights on Recognition & Risk Factors
ACP 2025: Foluso Fakorede, MD, discusses the importance of recognizing and screening for peripheral artery disease in primary care.
FDA Approves STS101 (Dihydroergotamine) Nasal Powder for Acute Treatment of Migraine
The only approved DHE nasal powder addresses persistent limitations of existing DHE formulations, including liquid nasal sprays and injectables, Satsuma stated.
Mepolizumab Reduces AER in COPD Leading to Emergency Care by 35%: MATINEE Findings Published in NEJM
Mepolizumab also cut annualized exacerbation rates by 21% across the full study cohort and by 31% in a subgroup of participants with chronic bronchitis only.
Burden of Moderate to Severe Atopic Dermatitis Weighs Heavily on Children and Adolescents: Real-World Analysis
The burden of disease was particularly pronounced among adolescents, including significantly greater impact on quality of life and psychosocial interaction.
Signs of Alzheimer Disease vs Age-Related Changes
Occasional trouble finding a word reflects typical age-related brain changes; the changes that cause a person to refer to a watch as a "hand clock" are not the same.
The Toll of Atopic Dermatitis is More than Skin Deep: Q & A with Harvard Child Psychologist Jennifer LeBovidge, PhD
Awareness of the psychological burden of eczema is improving, LeBovidge says, but if clinicians don't address mental health, patients and families will suffer in silence.
High Blood Pressure Advisory in EHR Improves Hypertension Diagnosis, Control Across a Primary Care Network
An EHR advisory that combined alerts to medical assistants with escalation to clinicians increased likelihood of hypertension control by a mean 18% per month.
Loneliness Poses a Critical Barrier to Chronic Care Management
A new survey found that the loneliness linked to a diagnosis of chronic illness saps motivation to seek regular care and almost universally to take medications as prescribed.
Alzheimer Disease in 2025: American Perspectives
US adults want to know early on if they have Alzheimer disease, when treatment may slow it, and they are willing to participate in trials of new drugs.
Amyloid and Tau Biomarkers of Alzheimer Disease Found in Individuals with Other Dementias
Biomarkers in a pattern characteristic of Alzheimer pathology were identified in unspecified dementia, Parkinson dementia, and frontotemporal dementia.
Switching Anti-CGRP Monoclonal Antibody Therapy in Nonresponders with Migraine May Reduce Monthly Headache Days
Subgroup analyses found no significant difference in efficacy based on change in therapeutic action (ie, CGRP vs its receptor), doses, or intertreatment interval.
AI Detects Nearly One-Third of Breast Cancers Previously Undetected by Radiologists on DBT Imaging
The AI program also correctly identified 90% of true positive cases, according to new data presented at the Society for Breast Imaging's annual symposium.
Metabolic Syndrome Linked to Risk of Young Onset Dementia
Authors found a dose-response relationship between MetS and dementia onset in the 4th decade; in those with all 5 components, risk of dementia was increased by 77%.
Endemic Measles is a Clear and Present Danger, According to Stanford University Modeling Study
At current vaccination rates, measles could become endemic in the US again within 21 years; the threat extends to rubella, polio, and diphtheria, the study found.
Postpartum Hormonal Contraceptive Use Linked to Increased Risk of Depression
The increased risk of depression when oral contraceptives were started following childbirth was "instantaneous," researchers wrote, and was ~50% greater than nonuse.
Precision Obesity Medicine Breakthroughs To Lead DDW 2025 Presentations from Phenomix Sciences
Phenomix will showcase new data on prediction of adverse events to GLP-1 RA therapy, a new obesity sub-phenotype, and approaches to improve surgical outcomes.
The Role for CGM in Glycemic Management Will Continue to Expand, Including in Prediabetes, Expert Says
CGM is now standard of care in T1D and evidence is solid for a role in insulin-treated T2D; Thomas Martens, MD, shares thoughts on CGM growth in the next 3-5 years.
How to Maximize CGM Data Presented in the Ambulatory Glucose Profile: Thomas Martens, MD, Illustrates
Martens, medical director of the International Diabetes Center (IDC) in Minneapolis, highlights an IDC resource that helps target problem areas in management of hyperglycemia.
Smoking Rates Hit New Low, But Cervical Cancer Screening Still Lags: 2025 ACS Report
While smoking in the US continues to decline, the American Cancer Society reports mixed progress in major cancer risk factors, prevention, and screening.
False Beliefs about MMR Vaccine, Measles Reach the Majority of US Adults: KFF Poll on Health Information & Trust
Misinformation about measles and the MMR vaccine has reached the majority of US adults and parents; most believe the vaccine is safe but many are still unconvinced.
GRAIL to Share Real-World Data from 100,000 Galleri Multi-Cancer Detection Tests at 2025 AACR Meeting
GRAIL announced plans to present new support for the Galleri test's ability to simultaneously screen for multiple cancers plus its accuracy for cancer signal of origin prediction.
