FDA Proposed Rule Change Expands Use of Salt Substitutes to Lower NaCl Intake, Reduce Chronic Disease
The rule change would provide flexibility in standards that govern specific ingredients used in food production, permitting replacement of regular sodium with less toxic substitutes.
Friday's 5 Quotes for Primary Care: 3-24-2023
Statin-eligible patients in minority groups significantly undertreated; metabolically healthy obesity on the rise; menstruation irregularities suggest later CVD risk; and 2 more studies of note.
Dupilumab Achieves Outcomes in Phase 3 COPD Clinical Trial "Never Before Seen with a Biologic"
Dupilumab in patients with uncontrolled COPD reduced annual exacerbations by 30%, a statistically significant and clinically meaningful outcome and a first for a biologic.
3 Things Primary Care Should Remember About Sports Medicine
A sports medicine specialist talks about collaborating with primary care and says there are 3 things that help make the partnership work so well.
Rate of Statin Use for Primary ASCVD Prevention Substantially Lower in Black, Hispanic Persons
Analysis of NHANES data between 2013-2020 found statin use low across racial/ethnic groups and significantly lower among Black and Hispanic participants.
AHA/ACC Release Scientific Statement on Benefits of Exercise Training in Persons with HFpEF
Studies on supervised exercise training in patients with chronic, stable HFpEF suggest substantial improvements in exercise capacity and QoL that may surpass those seen with medication.
Menstrual Cycle Irregularities May Increase Risk for Cardiometabolic Events in Later Life
Women whose menstrual cycle varied in frequency had a significant 24% greater risk of a composite cardiovascular event during a 26-year follow-up, a new study reports.
21st Century Sports Medicine: Not Your Grandfather's Concussion Protocol
Kevin Carneiro, DO, sports medicine specialist and medical director of the UNC Center for the Study of Retired Athletes, looks at the evolution of the specialty and its objectives.
Women with Severe Mental Illness Benefit from Continuing Antidepressant Use During Pregnancy
A new study found the probability of initiating psycholeptics and having a postpartum psychiatric emergency was lower in early and late discontinuer groups vs the continuer group.
Meningococcal ABCWY Vaccine Candidate Meets All Endpoints in Pivotal Phase 3 Trial
The 5-in-1 vaccine candidate, if approved, would provide the broadest meningococcal serogroup coverage and simplify the vaccination schedule.
Friday's 5 Quotes for Primary Care 3-17-2023
Each of the quotes is taken from a study reviewed on Patient Care during the week and was chosen for the research team’s passion about the implications of their findings.
Investigational Nonhormonal Treatment for Vasomotor Symptoms of Menopause Found Safe, Effective
Fezolinetant, a nonhormonal selective neurokinin-3 receptor antagonist, significantly reduced frequency and severity of menopause-related VMS in a pivotal phase 3 trial.
A UNC Sports Medicine Specialist Explains what Sports Medicine Really Is
Kevin Carneiro, DO, a sports medicine specialist and medical director of the UNC Center for the Study of Retired Athletes, details the broad scope of the specialty and his practice.
Shorter Primary Care Visits Linked to Inappropriate Prescribing Patterns, Study Finds
Shorter office visit length increased risk for inappropriate antibiotic prescribing, coprescribing of opioids and benzodiazepines, and potentially harmful prescriptions for seniors.
ACC 2023: 10 Clinical Highlights for Primary Care
Ketogenic diet comes with cautions, new benefits of bempedoic acid, how to increase GDMT for type 2 diabetes, and CV consequences of cannabis lead findings from ACC 2023.
Perceived Racism Linked to Significantly Increased Risk for Heart Disease in Black Women
Black women who reported perceived interpersonal racism in employment, housing, and interactions with police had a nearly 30% higher risk of CHD than those reporting none.
Perceived Stress Linked to Cognitive Impairment among Older Adults in the REGARDS Study
Screening for stress among older adults who present to primary care with signs of cognitive impairment could be key to reducing risk and targeting intervention, study authors say.
FDA Approves First Intranasal CGRP Receptor Antagonist for Adult Migraine
Zavegepant, the first FDA-approved intranasal CGRP receptor antagonist, could be available in pharmacies by July 2023.
Friday's 5 Quotes for Primary Care 3-10-2023
Each of the quotes is taken from a study reviewed on Patient Care during the week and was chosen for the research team’s passion about the clinical implications of their findings.
This Early Long COVID Clinic Was Led by PM&R and Family and Internal Medicine
The University of Washington in Seattle opened one of the country's first long COVID clinics, staffed by specialists in rehabilitation and primary care.
FDA Accepts sNDA for Empagliflozin for Children with Type 2 Diabetes Aged 10 Years and Older
The SGLT-2 inhibitor, if approved for this age group, would be the first agent in the class with the indication as adjunctive treatment for T2D for those younger than age 18.
Residual Inflammation in Statin-treated Patients Linked to Greater Risk for MACE, Mortality vs Residual Cholesterol
Among patients in the highest quartile of hsCRP, the risks of CV-related and all-cause death were more than 2 times higher than in those in the highest quartile of LDL-C.
A Primary Care Physician and a Physiatrist Share Notes on Sharing Patients
In a multidisciplinary primary care outpatient clinic, PCP Maisterra and physiatrist McMullen confer and refer on a regular basis and patients always win.
Ketogenic Diet Associated with Increased Serum Lipids, 2-fold Greater Risk of MACE
ACC2023. Risk for MACE was nearly 7-fold higher in participants on a keto diet whose LDL-C was already high compared with those on a standard diet with LDL-C in a normal range.
Likelihood of Optimal GDMT for Patients with T2D, ASCVD Increased with Multifaceted Clinic Intervention
ACC2023. For high-risk T2D patients not receiving optimal treatment for hyperlipidemia, hypertension, or hyperglycemia, intensive, multidisciplinary training for clinic staff could shift practice.
Primary Care and Physical Medicine & Rehab: In Conversation
Two clinicians from a multispecialty primary care outpatient clinic in Seattle talk about how they work together and the benefits of sharing their space and their patients.
Post-CABG Risk Remains Higher for Women vs Men with No Change Over Last 10 Years
After coronary artery bypass surgery, women are still at higher risk for MI, stroke, and other adverse events than men despite years of improvement in technique and care.
13 Medications to Avoid in Adults with Hypertension: A Guideline Topline for Primary Care
Reduce potential for promoting or worsening hypertension by stopping, reducing, or using alternatives to these 13 drugs and substances.
Nerivio Prescription Wearable Cleared by FDA for Preventive Treatment of Migraine
The prescription remote electrical neuromodulation device is now cleared for both acute and preventive treatment of migraine in those aged ≥12 years, according to Theranica.
FDA Advisory Committee Votes in Support of Safety, Efficacy of GSK Adult RSV Vaccine Candidate
The VRBPAC vote that the GSK data support the vaccine's efficacy was unanimous and on safety the vote was 10-2. PDUFA date set for May, 2023.