Lowering Daily Sodium Intake May Reduce AF Risk in Vulnerable Adults
An analysis of 28 000 adults with vascular disease and high-risk diabetes found daily sodium intake of ≥8 g significantly increased risk for AF by 32%.
Intranasal Flu Vaccine Coadministered with High-Dose Shot More Effective in Older Adults than Shot Alone
The investigational live intranasal vaccine was safe and well-tolerated when given concomitantly with Fluzone HD and the combination outperformed the latter given by itself.
GRAIL Multicancer Early Detection Test Registrational Trials Make Good Progress, Company Says
The PATHFINDER 2 and HMS-Galleri trials are proceeding as planned with more than 175 000 participants from diverse backgrounds enrolled across both.
Novel Combination Treatment is Potent Driver of Beta Cell Proliferation in Type 1 Diabetes Model
In the mouse model of type 1 diabetes, a combined harmine/exendin-4 therapy resulted in an up to 7-fold increase in β cell numbers over 3 months, reported investigators.
Combined SGLT2i and GLP-1 RA Therapy Provides Complementary Cardiorenal Protection, According to Comprehensive Meta-Analysis
Findings from the large meta-analysis provide strong support for use of both classes to reduce CV and renal disease in adults with type 2 diabetes.
Roflumilast Cream 0.15% Approved for Treatment of Atopic Dermatitis in People Aged 6 Years and Older
The steroid-free cream was developed for long-term use and has been proven safe in an open-label extension study following successful phase 3 trials.
FDA Issues CRL to Novo Nordisk for Once-Weekly Insulin Icodec
The agency is concerned about manufacturing processes involved in production and about the proposed indication for adults with type 1 diabetes.
In the Old and Very Old, Statins Appear Safe for Primary CVD Prevention, New Analysis Finds
Continuous statin use among adults aged 75 years and older resulted in a mean relative risk reduction in CVD of 28% without heightened safety concerns, a new study found.
Prenatal RSV Vaccine Not Associated with Preterm Birth, According to First Real-World Data
Data from a study performed during the first season the shot was available expand on clinical trial evidence and support the safety of RSVpreF, authors wrote.
Weight Loss with Tirzepatide Significantly Greater than with Semaglutide: New Data
Tirzepatide-treated participants were 3 times more likely than those treated with semaglutide to reach weight loss of 15% or greater, the head-to-head study found.
Exercise Plus GLP-1 RA May Preserve BMD During Weight Loss, Study Finds
The preserved bone mass observed in participants taking liraglutide and exercising was seen despite weight reduction levels similar to outcomes with semaglutide and tirzepatide.
Lilly's Donanemab Approved by FDA for Treatment of Early Symptomatic AD
Donanemab, now 1 of 2 antiamyloid medications available, is unique based on evidence that it can be used in limited duration treatment, based on removal of plaque.
First Consensus Guidance Published on Monitoring Early-Stage Type 1 Diabetes
The international statement targets primary care clinicians and endocrinologists with detailed guidance on monitoring disease progression and providing education.
UPDATE: ACIP Vote Unanimous to Recommend Merck 21-Valent Pneumococcal Shot for Older Adults
The novel vaccination is recommended as an option for adults aged 65 years and older who have not received a pneumococcal conjugate vaccine.
FDA Accepts 2 NDAs, Grants Priority Review for Crinecerfont for Pediatric, Adult CAH
Neurocrine Biosciences made the announcement and said, if approved in December, crinecerfont will be the first new treatment and treatment approach to CAH in 70 years.
Management of Congenital Adrenal Hyperplasia in Adults: Challenges with Standard of Care
The standard of care for congenital adrenal hyperplasia has not changed in more than 60 years nor have the challenges it presents been overcome.
Emerging Therapies in Management of Congenital Adrenal Hyperplasia
Investigational treatments for congenital adrenal hyperplasia are focused on new ways to manage symptoms without the need for supraphysiologic doses of glucocorticoids.
Androgen Management in Congenital Adrenal Hyperplasia: A Primer
Current therapies fall short of quelling the long-term exposure to and adverse effects of excessive androgen levels experienced by adults with CAH.
ACIP Revises Recommendation for Adult RSV Vaccination
The committee endorsed a universal recommendation for a single lifetime dose of RSV vaccine for adults aged ≥75 years and a risk-based recommendation for those aged 60 to 74 years.
Older US Adults Without CVD Still Using Aspirin for Primary Prevention
Nearly one-third of US adults aged 60 years and older continue to take daily aspirin despite published evidence recommending against use in the absence of CVD.
CGM Data May Enhance Prediction of Risk for Type 1 Diabetes in Those with Early Stage Disease
ADA 2024. The risk of progression to stage 3 type 1 diabetes may be better predicted using a combination of patient and CGM data, a new study suggests.
Pemvidutide Preserves Lean Mass With Weight Loss of Nearly 16%: MOMENTUM Phase 2 Trial
ADA 2024. MOMENTUM trial findings presented at the ADA yesterday showed 78.1% of weight loss attributable to loss of fat vs lean mass in adults with overweight or obesity.
After ACS, Long-Term Lipid Management for FH Suboptimal in Women Compared to Men
Fiver years after ACS, a new study shows women are less likely to be on lipid lowering therapy and to meet LCL-C target levels than men.
USPSTF Recommends Intensive Behavioral Interventions for Children, Teens with High BMI
The grade B recommendation (moderate certainty) targets youth aged 6 years and older with a BMI at or above the 95th percentile for age and sex.
George L Bakris, MD, Expert in Hypertension and Metabolic Disease, Has Died
Described as a giant and a pioneer in the hypertension and metabolic fields, Bakris is also remembered so fondly by colleagues as a very special man.
Chronic Hypertension in Pregnancy Increased Two-Fold Between 2008 and 2021
The doubling of the diagnosis of chronic hypertension in pregnancy was accompanied by no increase in treatment rates, according to a new study.
Dapagliflozin Approved by FDA to Improve Glycemic Control in Children, Adolescents with T2D
Among youth aged 10 to 17 years with uncontrolled hyperglycemia dapagliflozin led to a statistically significant reduction in A1c vs placebo in the T2NOW phase 3 clinical trial.
FDA Approves Merck's 21-Valent Pneumococcal Vaccine for Adults 50 Years of Age and Older: A First and Long-Awaited
Capvaxive is the only pneumococcal vaccine formulated specifically to protect adults 50 years and older from IPD and elicited robust immune responses in both vaccine-naïve and vaccine-experienced adults.
Defining Long COVID: Highlights from the National Academy of Sciences Consensus Report
In part the National Academies describe long COVID as "a chronic, systemic disease state with profound consequences." The report provides a working definition.
Phase III Trials Show Depemokimab Reduces Severe Asthma Exacerbations with Twice-Yearly Dosing
The high potency IL-5 inhibitor can be administered every 6 months, offering a convenient alternative to other biologic agents for appropriate patients with severe asthma.
