Semaglutide 2.4 mg Significantly Reduces HF Symptom Burden, Body Weight in Adults with HFpEF and Obesity
ESC Congress 2023. The results of STEP-HFpEF could "change the nature of the conversation about the role of obesity in HFpEF," said PI Mikhail Kosiborod, MD.
Remdesivir Gets FDA “OK” for COVID-19 Treatment in Hepatic Disease Across Stages
The expanded labeling for the antiviral against COVID-19 indicates no dose adjustment is required for persons across all stages of liver disease.
Cardiorenal Risk Estimates in T2D Mediated by Common Biomarker Response to Canagliflozin
Reduction in levels of 4 biomarkers was correlated with lower risk of composite cardiorenal outcomes in the CREDENCE trial, suggesting use of the panel to augment current risk assessment tools.
USPSTF Publishes Final Recommendation Statement on HIV PrEP
The USPSTF particularly emphasizes effective communication with patients, including adherence support and calls for reducing barriers to PrEP for racial, ethnic, and other minority groups.
Top 10 Nonfatal Injuries Seen in US Emergency Departments
The most common nonfatal injuries are caused by unintentional falls; coming in at #10 are pedal cyclist injuries. Find out what calamities lie in between in a short slide show.
Semaglutide 2.4 mg Could Reduce US Obesity by Half, Prevent 1.5 million CVD Events
More than 90 million adults in the US with overweight/obesity are candidates for weight loss treatment with semaglutide 2.4 mg, according to a new study.
NIH Designates Centers of Excellence to Improve Maternal Health Equity
The newly named centers across the country will work closely with communities to focus research on populations at greatest risk for perinatal morbidity and mortality.
Vitamin D Deficiency Linked with Recurrent C diff Infection in New Cross-Sectional Study
Patients hospitalized for Clostridioides difficile infection who also were vitamin D-deficient were at higher risk of recurrence—but lower risk of mortality.
Long-term Smokers Have Symptomatic Lung Disease that is Not COPD, Has No Treatment
Despite a 20-pack year smoking history and frequent respiratory exacerbations, spirometry is preserved in this group of heavy smokers.
Social Determinants of Health Drive CVD Mortality Differences Between Black and White Adults
Excess CVD mortality among Black vs White adults was diminished after control for behavior/metabolic factors and negligible after adjustments for SDOH, a new study reveals.
Sotagliflozin Cut Risk by >50% for HF Rehospitalization and CV Death when Started Before Discharge
A post hoc analysis of the landmark SOLOIST-WFH trial supports avoiding delay in initiating the SGLT-2/1 inhibitor as part of guideline-recommended treatment.
Wegovy Keeps Winning; Bye-bye Baby Blues; SPRITE After Menopause; +2: The Five for Friday
Antiobesity drug reduces CVD risk; postpartum depression Rx approved; sugary drinks up adverse hepatic events in older women; cuff size does matter, more.
Daily Sugared Drink Consumption May Increase Risk of Hepatic Morbidity, Mortality in Older Women
Postmenopausal women who consumed 1 or more sugary drinks daily had a nearly 2-fold increased risk of liver cancer in a study of more than 98 000.
Prescription "Weight Loss" Drugs: Americans Voice an Opinion
Most Americans are aware of the hot prescription drugs associated with weight loss and many are interested in using them. But access and administration are problematic.
Antiobesity Medication Semaglutide 2.4 mg Reduced Risk of MACE by 20%: Topline Results from Landmark SELECT Trial
The reduction in risk of CV events, the first to be shown by an antiobesity drug, was higher than expected and could help alter perceptions of the agents as "lifestyle drugs."
For Accurate BP Measurement, Cuff Size Must Be "Just Right"
Blood pressure cuffs that are too large or too small for an individual's upper arm return measurements that may misguide therapeutic decisions, say study authors.
Atogepant Reduces Monthly Migraine Days vs Placebo in Persons with Chronic Migraine
The oral gepant reduced monthly migraine days as well as mean monthly use of migraine rescue medication.
Start CRC Screening When? Statigenarians, ETOH and HTN, +2: The Five for Friday
ACP CRC first screening age questioned; elders over age 75 years respond better to statins; 1 drink/day ups risk for HTN; OTC lifesaver #2; plus a triple virus assay.
The Moderna mRNA COVID-19 Vaccine May Be Safer in Older Adults than the Pfizer Shot, New Study Suggests
The only head-to-head trial of mRNA COVID-19 vaccine safety in older adults finds one has a slight edge over the other, which might just be enough for some patients.
Merck's 21-Valent Adult Pneumococcal Vaccine Meets Key Endpoints in Pair of Phase 3 Trials
Statistically significant positive immune responses were observed in both vaccine-naive adults and those previously vaccinated, including for the vaccine's 8 unique serotypes.
FDA Grants 501(k) Clearance to Triple Assay for Influenza, RSV, and COVID-19
The triple assay can identify and differentiate influenza, COVID-19, and respiratory syncytial virus in approximately 2 hours and is already in use.
Influenza Vaccination 2023-2024: ACIP Recommendations and Changes
ACIP guidance on influenza vaccination for the 2023-2024 respiratory virus season includes updates important for primary care clinicians.
ACP Updates Guidance on Screening for Colorectal Cancer, Maintains Age 50 Years to Start
The American College of Physicians in the updated guidance maintains the risk/benefit ratio supports screening initiation at age 50 (vs 45) years.
The Primary Care-PM&R Collaboration Can Help Keep Patients Out of the OR
His relationship with primary care physicians is one of the most important, says physiatrist DJ Kennedy, MD, and he lists the reasons in this interview.
Drinking Even 1 Alcoholic Beverage per Day May Increase Risk for Hypertension, Study Finds
The association between ETOH consumption and hypertension among 19 500 healthy adults was "direct and linear," a new dose-response meta-analysis found.
US Albuminuria Testing Far Below Levels Essential for Effective CKD Treatment
Among persons with hypertension and T2D with albuminuria, nearly two-thirds currently go undetected, a significant barrier to diagnosis and treatment of CKD.
New Technologies Will Propel Novel Approaches in PM&R, says AAPM&R President-Elect
Physiatrist DJ Kennedy, MD, is excited by the potential for new, and even existing technology, to present novel options for diagnosis, monitoring, and treatment.
Mean Weight Loss with Tirzepatide Reaches 26% Across 2 Pivotal Phase 3 Clinical Trials
In adults with obesity or overweight plus comorbidities but without T2D once-weekly tirzepatide was associated with significant and durable weight loss vs placebo.
A no-go for aspirin, Vegetarian victory, Opioids and dementia +2: The Five for Friday
No aspirin for healthy elders, Vegan diets vs CVD, Opioids deadly in dementia, plus BP patterns in babies, and the fear of Alzheimer's runs deep.
Daily Dose: Death Often Follows First Opioid After Dementia Dx
A daily dose of clinical news on Patient Care you may have missed.
