Daily Dose: "Night Owls" Less Healthy, at Higher Risk for T2D
Your daily dose of the clinical news you may have missed.
Dupilumab Potent Against Uncontrolled COPD with T2 Inflammation: BOREAS Trial Update
Reduced exacerbations, improved lung function, increased QoL, and less use of systemic corticosteroids underscore dupilumab's effects against type 2 inflammation.
One in 5 US Adults Mixes Alcohol with Alcohol-Interactive Medications
Primary Care Alert: Risky alcohol use in the past year was found highest among persons taking benzodiazepines, followed by those taking opioids, and taking antiepileptics.
Lorundrostat Phase 2 Trial Results Suggest Potential Efficacy Against Uncontrolled and Resistant Hypertension
The selective aldosterone synthase inhibitor will move into late stage clinical trials, a nod to the potential for a first-in-class agent targeting aldosterone.
Evening Chronotype in Women Linked with Unhealthy Lifestyle, Increased Risk for Type 2 Diabetes
Women with an evening vs morning chronotype were 54% more likely to have unhealthy lifestyles that in turn accounted for a significant increased risk for diabetes.
FDA Approves Updated COVID-19 Monovalent Vaccines for 2023-2024
As COVID-19 hospitalizations increase at the opening of the respiratory virus season, the first "seasonal" vaccine against the virus is ready for roll-out, says the FDA.
The Worst States for Health Care in the US: 2023
Get a quick look at the US worst states for health care ranked using a composite score that included measures of cost, access, and outcomes.
Keep the Vaccination Conversation Going—and Cheerlead, Too
"Keep the vaccination conversation going this year, even though your patients, and probably you, too, have grown tired of the issues and your team is worn out."
The Best States for Health Care in the US: 2023
The best states for health care were ranked using a composite score that included measures of cost, access, and outcomes. So, which state retains the most residents?
3 Dangerous Respiratory Viruses, 3 Robust Vaccines, 3 Shots at Broad Protection This Year
SARS-CoV-2, influenza, and respiratory syncytial virus are all targets this flu season for family physician Chuck Vega, MD, who says he's "going for all 3."
The Respiratory Syncytial Virus Vaccine for Older Adults: The New Shot on the Block
RSV is comparable to influenza every year in the severity of infection among older adults. Drs Bill Schaffner and Chuck Vega say both patients and clinicians will need education this season.
Osteoarthritis Projected to Affect Nearly 1 Billion by 2050, Obesity a Major Contributing Factor
Three key drivers of the perennial increase in OA prevalence are population growth, aging, and obesity, said authors of the analysis for the Global Burden of Disease study.
Satisfaction with IUD High, Rate of Unprotected Sex Low after Placement Following Medical Abortion
IUD placement within 48 hours of medical abortion was associated with high satisfaction, continued use, and low rates of subsequent pregnancies, report Swedish investigators.
Semaglutide 2.4 mg Significantly Reduces HF Symptom Burden, Body Weight in Adults with HFpEF and Obesity
ESC Congress 2023. The results of STEP-HFpEF could "change the nature of the conversation about the role of obesity in HFpEF," said PI Mikhail Kosiborod, MD.
Remdesivir Gets FDA “OK” for COVID-19 Treatment in Hepatic Disease Across Stages
The expanded labeling for the antiviral against COVID-19 indicates no dose adjustment is required for persons across all stages of liver disease.
Cardiorenal Risk Estimates in T2D Mediated by Common Biomarker Response to Canagliflozin
Reduction in levels of 4 biomarkers was correlated with lower risk of composite cardiorenal outcomes in the CREDENCE trial, suggesting use of the panel to augment current risk assessment tools.
USPSTF Publishes Final Recommendation Statement on HIV PrEP
The USPSTF particularly emphasizes effective communication with patients, including adherence support and calls for reducing barriers to PrEP for racial, ethnic, and other minority groups.
Top 10 Nonfatal Injuries Seen in US Emergency Departments
The most common nonfatal injuries are caused by unintentional falls; coming in at #10 are pedal cyclist injuries. Find out what calamities lie in between in a short slide show.
Semaglutide 2.4 mg Could Reduce US Obesity by Half, Prevent 1.5 million CVD Events
More than 90 million adults in the US with overweight/obesity are candidates for weight loss treatment with semaglutide 2.4 mg, according to a new study.
NIH Designates Centers of Excellence to Improve Maternal Health Equity
The newly named centers across the country will work closely with communities to focus research on populations at greatest risk for perinatal morbidity and mortality.
Vitamin D Deficiency Linked with Recurrent C diff Infection in New Cross-Sectional Study
Patients hospitalized for Clostridioides difficile infection who also were vitamin D-deficient were at higher risk of recurrence—but lower risk of mortality.
Long-term Smokers Have Symptomatic Lung Disease that is Not COPD, Has No Treatment
Despite a 20-pack year smoking history and frequent respiratory exacerbations, spirometry is preserved in this group of heavy smokers.
Social Determinants of Health Drive CVD Mortality Differences Between Black and White Adults
Excess CVD mortality among Black vs White adults was diminished after control for behavior/metabolic factors and negligible after adjustments for SDOH, a new study reveals.
Sotagliflozin Cut Risk by >50% for HF Rehospitalization and CV Death when Started Before Discharge
A post hoc analysis of the landmark SOLOIST-WFH trial supports avoiding delay in initiating the SGLT-2/1 inhibitor as part of guideline-recommended treatment.
Wegovy Keeps Winning; Bye-bye Baby Blues; SPRITE After Menopause; +2: The Five for Friday
Antiobesity drug reduces CVD risk; postpartum depression Rx approved; sugary drinks up adverse hepatic events in older women; cuff size does matter, more.
Daily Sugared Drink Consumption May Increase Risk of Hepatic Morbidity, Mortality in Older Women
Postmenopausal women who consumed 1 or more sugary drinks daily had a nearly 2-fold increased risk of liver cancer in a study of more than 98 000.
Prescription "Weight Loss" Drugs: Americans Voice an Opinion
Most Americans are aware of the hot prescription drugs associated with weight loss and many are interested in using them. But access and administration are problematic.
Antiobesity Medication Semaglutide 2.4 mg Reduced Risk of MACE by 20%: Topline Results from Landmark SELECT Trial
The reduction in risk of CV events, the first to be shown by an antiobesity drug, was higher than expected and could help alter perceptions of the agents as "lifestyle drugs."
For Accurate BP Measurement, Cuff Size Must Be "Just Right"
Blood pressure cuffs that are too large or too small for an individual's upper arm return measurements that may misguide therapeutic decisions, say study authors.
Atogepant Reduces Monthly Migraine Days vs Placebo in Persons with Chronic Migraine
The oral gepant reduced monthly migraine days as well as mean monthly use of migraine rescue medication.