AAFP President-Elect Steven Furr, MD, Talks About Vaccination in Practice vs in Theory
Furr on COVID-19 shot: The expectation that 90% of the US population would take this new vaccine that they'd never heard of was probably not practical.
Moderna Investigational Dual Flu/COVID-19 Vaccine Shows Positive Phase 1/2 Results
The combination was found equally as effective as 2 standard influenza vaccine comparators and as the Moderna Spikevax COVID-19 booster shot.
Use of Maintenance Therapy Suboptimal Before Asthma Exacerbations, New Research Finds
Many patients with moderate-to-severe asthma may not be using inhaled corticosteroids along with rescue medications to avoid serious disease exacerbations.
In Older Adults with T2D, Clinical Decision Support Tool Can Reduce Hypoglycemia
In adults older than age 65 years with T2D, a simple clinical decision support tool plus shared decision making reduced hypoglycemic episodes by half.
FDA Adds New Warnings to Labeling for Ozempic
The addition of ileus as a potential adverse event associated with the GLP-1 mimetic is not the first required for the class by the regulator.
One or More Cardiac, Renal, or Metabolic Conditions Affect 25% of US Adults
The prevalence of cardiac, renal, and metabolic conditions has significantly increased over 20 years and so has the number of US adults who have all 3.
A Pediatric Rehabilitation Physician's View on Poverty as Cause and Consequence of Disability
Amy Houtrow, MD, PhD, MPH, considers the impact of poverty on childhood disability and talks about opportunities to breach barriers to health care access.
Adding 3000 Ordinary Steps/Day Reduced BP in Sedentary Older Adults with Hypertension
An e-health lifestyle walking intervention partially supported by remote coaching led to significant improvement in BP in older adults as well as a desire to keep walking.
Oral vs Transdermal Hormone Therapy after Menopause Linked to Increased Risk of NAFLD
Among postmenopausal women taking hormones orally, the NAFLD prevalence increased from 25.3 to 29.4% while it decreased from 24 to 17.3% in those using the transdermal route.
GLP-1 Mimetics, SGLT-2 Inhibitors Understudied in Black Populations in Pivotal Trials, Benefits Questioned
Pivotal cardiovascular outcome trials that evaluated cardiorenal benefits of the newer classes were not designed to consider racial/ethnic variations, researchers state.
Biosimilar Liraglutide Noninferior to Reference Product in Persons with Type 2 Diabetes: Phase 3 Trial
The biosimilar to the GLP-1 mimetic Victoza proved noninferior for reduction of HbA1c and had similar positive effects on body weight, lipids, and blood pressure.
Waist-to-Hip Ratio More Consistently Associated with Mortality vs BMI: New Research
Waist-to-hip ratio was more powerfully and consistently associated with risk of all-cause mortality than BMI or FMI, but can it replace BMI as a clinical indicator?
Long-COVID Rehabilitation Interventions Improve Symptoms but Research on Safety Still Needed
Meta-analysis: Among persons with symptoms of long COVID, respiratory and exercise training were effective but pooled information on safety was "uncertain, imprecise."
Fatigue Common in Migraine, More Severe in Chronic vs Episodic Disease
Fatigue was positively correlated with frequency, duration, severity and chronicity of migraine episodes and more common among chronic migraineurs, a new study reveals.
USPSTF Publishes Final Guidance on Screening for Hypertensive Disorders of Pregnancy
The USPSTF recommends that BP be checked at all prenatal visits for all pregnant persons and calls for reducing vast inequities in maternal health care.
Novel Factor XI Inhibitor Abelacimab Found Superior to Rivaroxaban in Phase 2b Trial with High-Risk Cohort
The AZALEA-TIMI 71 trial was stopped early due to an "overwhelming reduction" in a composite endpoint of major bleeding events compared to rivaroxaban standard of care.
FDA Accepts Resmetirom NDA, Grants Priority Review, and Sets PDUFA Date
Resmetirom, a once-daily oral, thyroid hormone receptor (THR)-β selective agonist, targets key underlying NASH pathophysiology in the liver.
Daily Dose: "Night Owls" Less Healthy, at Higher Risk for T2D
Your daily dose of the clinical news you may have missed.
Dupilumab Potent Against Uncontrolled COPD with T2 Inflammation: BOREAS Trial Update
Reduced exacerbations, improved lung function, increased QoL, and less use of systemic corticosteroids underscore dupilumab's effects against type 2 inflammation.
One in 5 US Adults Mixes Alcohol with Alcohol-Interactive Medications
Primary Care Alert: Risky alcohol use in the past year was found highest among persons taking benzodiazepines, followed by those taking opioids, and taking antiepileptics.
Lorundrostat Phase 2 Trial Results Suggest Potential Efficacy Against Uncontrolled and Resistant Hypertension
The selective aldosterone synthase inhibitor will move into late stage clinical trials, a nod to the potential for a first-in-class agent targeting aldosterone.
Evening Chronotype in Women Linked with Unhealthy Lifestyle, Increased Risk for Type 2 Diabetes
Women with an evening vs morning chronotype were 54% more likely to have unhealthy lifestyles that in turn accounted for a significant increased risk for diabetes.
FDA Approves Updated COVID-19 Monovalent Vaccines for 2023-2024
As COVID-19 hospitalizations increase at the opening of the respiratory virus season, the first "seasonal" vaccine against the virus is ready for roll-out, says the FDA.
The Worst States for Health Care in the US: 2023
Get a quick look at the US worst states for health care ranked using a composite score that included measures of cost, access, and outcomes.
Keep the Vaccination Conversation Going—and Cheerlead, Too
"Keep the vaccination conversation going this year, even though your patients, and probably you, too, have grown tired of the issues and your team is worn out."
The Best States for Health Care in the US: 2023
The best states for health care were ranked using a composite score that included measures of cost, access, and outcomes. So, which state retains the most residents?
3 Dangerous Respiratory Viruses, 3 Robust Vaccines, 3 Shots at Broad Protection This Year
SARS-CoV-2, influenza, and respiratory syncytial virus are all targets this flu season for family physician Chuck Vega, MD, who says he's "going for all 3."
The Respiratory Syncytial Virus Vaccine for Older Adults: The New Shot on the Block
RSV is comparable to influenza every year in the severity of infection among older adults. Drs Bill Schaffner and Chuck Vega say both patients and clinicians will need education this season.
Osteoarthritis Projected to Affect Nearly 1 Billion by 2050, Obesity a Major Contributing Factor
Three key drivers of the perennial increase in OA prevalence are population growth, aging, and obesity, said authors of the analysis for the Global Burden of Disease study.
Satisfaction with IUD High, Rate of Unprotected Sex Low after Placement Following Medical Abortion
IUD placement within 48 hours of medical abortion was associated with high satisfaction, continued use, and low rates of subsequent pregnancies, report Swedish investigators.