Risk of Preeclampsia, Preterm Birth Prevented as Well by Low-dose Calcium as by Recommended High-Dose, Study Finds
Low-dose calcium supplementation with 500 mg/day may be as protective against poor pregnancy outcomes as the WHO-recommended dose of 1500 mg/day.
Risk for Incident Asthma and Exacerbations Increases with Atopic Dermatitis in Dose-Dependent Fashion: Study
The risk of asthma and poor outcomes was even greater among children with both conditions than among adults in this first study to compare the 2 populations.
Opioid with 'Overdose Protection' Formulation Wins FDA Breakthrough Designation
The investigational combination opioid from Ensysce Biosciences is designed to deter abuse as well as prevent accidental or intentional overdose, the company said.
More than Half of US Adults Still Don't Recognize Heart Disease as #1 Cause of Death
Heart disease has been the primary cause of death in the US for the last century, and yet 51% of adults do not recognize the fact.
Comorbid Depression and IBD Significantly Increases Risk of Hospital Readmission, Mortality, According to National Database Review
Already high rates of readmission and mortality at 30 days rose significantly higher at 90 days, according to this National Readmissions Database review.
FDA Approves Dupilumab for Eosinophilic Esophagitis in Children Aged 1 to 11 Years
Dupilumab is the first agent approved to treat EoE in this vulnerable pediatric population.
Individuals with IBD Hospitalized for COVID-19 at High Risk for Shock, Organ Injury Suggests National Analysis
Among more than 1.5 million persons hospitalized for COVID-19, a history of Crohn disease or ulcerative colitis significantly increased risk for poor outcomes.
In Crohn Disease, Biologic Dose Escalation is Common During Maintenance Phase, Study Reveals
"A meaningful percentage" of individuals with Crohn disease are treated during maintenance with biologic doses ≥20%higher than recommended in FDA labeling.
Baseline HbA1c Greater than 6.0% Linked to "Exponential" Increase in T2D Risk for Adolescents with Obesity
Adolescents with overweight or obesity and baseline HbA1c 6.3%-6.4% were at 72-fold greater risk for T2D than those with HbA1c of 5.5%, a new cohort study finds.
Contraceptive Services Must be Provided without Cost-Sharing: HHS Guidance Update
Targeting "impermissible" barriers created to no-cost contraception required by the ACA, the HHS guidance follows the Biden-Harris June 2023 Executive Order on the issue.
FDA Adds Black Box to Prolia PI Warning of Severe Hypocalcemia Risk in CKD
The Boxed Warning reflects FDA research into severe adverse events including hospitalization and death in persons with CKD treated with denosumab.
Diabetes Remission of Any Duration May Reduce Risk of Renal and Cardiovascular Disease:
Remission of T2D, regardless of duration of remission, was associated with reduced risk of diabetes-related CKD and CVD in a post hoc analysis of Look AHEAD.
Gabapentinoids May Increase Risk of Severe COPD Exacerbations, Warns New Study
In persons with COPD, use of the anticonvulsants was linked to a 39% increase in risk of severe disease exacerbation requiring hospital admission, study authors reported.
"Ozempic" and Older Adults: Awareness of & Views on Rx Medications for Weight Management
When it comes overweight, obesity, and prescription drugs for weight loss, these results from the National Poll on Healthy Aging suggest older US adults need guidance.
Bempedoic Acid Associated with 20% Reduction in Total CV Events in Prespecified CLEAR Outcomes Analysis
The protective effect of bempedoic acid appeared to increase with the number of CV events a study participant experienced, according to study authors.
Shelf-Life Extended for Narcan Nasal Spray, FDA Announces
This second shelf-life extension for the OTC naloxone hydrochloride 4 mg spray continues the FDA's campaign to prevent drug overdose and related fatalities.
Changes to the 2024 ACIP Adult Immunization Schedule: At-a-Glance
Changes to the ACIP adult schedule include new Notes on the RSV vaccines and updates to Notes on flu vaccination, COVID-19 vaccination, and the pentavalent MenB shot.
Nonprescription Weight Loss Products Used by 1 in 10 Adolescents Worldwide: New Meta-Analysis
Use of nonprescribed weight loss products was higher among girls than boys globally and led by diet pills, followed by laxatives and diuretics, a meta-analysis found.
Early Breastfeeding May Reduce Risk of Childhood Obesity, Regardless of Mother's BMI: NIH Study
Each additional month of breastfeeding beyond 3 months correlated with a significantly lower child BMIz, especially for mothers identified as overweight or obese.
Fibrosis Screening Results May Motivate Behavior Change in Adults at Risk of Liver Disease: Danish Study
Screening for fibrosis in persons at risk of ALD and MASLD led to sustained improvements in lifestyle, eg, reduced alcohol consumption, weight loss, and increased exercise.
Ustekinumab Maintenance Therapy for Ulcerative Colitis Safe, Effective at 4 Years: UNIFI-LTE
More than half of adults with moderate to severe UC maintained clinical and endoscopic remission at 4 years; nearly all no longer required corticosteroids, authors reported.
FDA Review Suggest No Link Between GLP-1RAs and Suicidal Thoughts but Surveillance Will Continue
While the FDA's preliminary evaluation has not surfaced evidence of a link, the agency says it "cannot definitively rule out that a small risk may exist," and so will continue research.
Dupilumab Reduces Nighttime Symptoms, Sleep Disturbance in Severe T2 Asthma
Use of dupilumab also eliminated the need for use of a rescue inhaler in more than one-third of treated patients and the number of inhalations needed for others.
COPD Exacerbations May Increase Risk of Severe CV Events by More Than 15-Fold: Cohort Study
The risk of severe CV events, including leading to death, was greatest in the first week following an exacerbation but remained significantly elevated 1 year later.
Elinzanetant Meets Safety, Efficacy Endpoints in Phase 3 Studies Of Menopausal VMS
The novel nonhormonal compound significantly reduced vasomotor symptoms and sleep disturbance while improving quality of life, according to findings.
Maternal Cannabis Exposure Linked to Placental Dysfunction-Related Adverse Pregnancy Outcomes
Cannabis use during pregnancy, particularly continued use beyond the first trimester, was associated with SGA birth, still birth, and hypertensive disorders of pregnancy, authors reported.
Hospitalization for COVID-19 vs for Influenza Linked to More, More Severe Long-Term Outcomes: Study
After hospital discharge, persons who had COVID-19 remained at greater risk of death and myriad adverse health outcomes compared with those who had seasonal flu.
NAFLD Linked to Adverse Outcomes Regardless of BMI, New Research Suggests
Individuals with "lean NAFLD" may be at similar risk of NASH, cirrhosis, nonliver cancer, and death as as those with NAFLD and overweight or obesity, authors say.
Older Adults with New Onset Migraine 3 Times More Likely to Have Motor Vehicle Accident
Older adults with a history of migraine, in contrast, were at no greater risk of an automotive crash than those without prevalent migraine, according to new study results.
Eli Lilly Open Letter Warns Against Use of Tirzepatide for "Cosmetic Weight Loss"
In an open letter to the public, Lilly decries use of tirzepatide products Mounjaro and Zepbound for nonmedical purposes and warns of counterfeit formulations.