Telemedicine Boosts Inhaler Technique, QoL After Severe COPD Exacerbations: Daily Dose
Your daily dose of the clinical news you may have missed.
Menopause Treatment in Real-World Practice: Ob/Gyn Anna Christine Cochrane, MD Highlights New Research
Cochrane shares her own research findings on how clinician specialty shapes menopause care and highlights gaps in hormone therapy prescribing.
Treatment of Vasomotor Symptoms: From Hormone Therapy to Neurokinin Receptor Antagonists
Larkin Larkin, MD, reviews treatment options for VMS, comparing hormone therapy effectiveness with antidepressants and new neurokinin antagonists.
Rising Youth Hypertension and Its Long-Term Impact on Coronary Disease: Two New Data Sets
A 2-fold rise in pediatric hypertension over 2 decades and new long-term imaging data signal a need to rethink how early clinicians act on elevated BP.
Quadrivalent modRNA Influenza Vaccine Shows Superior Efficacy to Licensed Inactivated Vaccine in Phase 3 Trial
Results showed that Pfizer’s mRNA vaccine cut influenza-like illness by 34.5% compared with a standard influenza vaccine.
Dual GCG/GLP-1 Agonist Mazdutide 9 mg Produces 20% Weight Loss in Phase 3 Trial of Chinese Adults with Obesity
GLORY-2 participants showed continuous weight loss through 60 weeks with no plateau; mazdutide also improved multiple cardiometabolic markers.
Physical Activity in Mid- and Late Life Linked to Markedly Lower Risk of Dementia
Life-course analysis sheds light on how movement patterns influence brain resilience, giving clinicians new context for counseling about dementia prevention.
Weekly Dose Podcast: FDA Breakthrough in Acromegaly, Alcohol–Dementia Risk Clarified, Tirzepatide in Youth T2D, Precision Mood Gains, and Major Contraception Practice Insights
Topics include new findings on oral acromegaly therapy, alcohol and dementia risk, tirzepatide in youth T2D, precision mood care, and LARC outcomes.
FDA Clears First CGM-Integrated Basal Insulin Dosing Optimizer for Adults With Type 2 Diabetes
FDA approves Dexcom Smart Basal, a groundbreaking CGM-integrated insulin dosing optimizer, enhancing diabetes management for adults with Type 2 diabetes.
Two Alzheimer Disease Therapies to Watch at CTAD 2025: Lecanemab and Sabirnetug Updates
Eisai and Acumen Therapeutics will present new data in areas including long-term outcomes, brain delivery strategies, and early-stage Alzheimer disease.
Blood-Based Colorectal Cancer Screening Test Achieves 95% Patient Adherence in Real-World Study
Real-world data from 20 000 patients demonstrate significantly higher adherence rates with Shield blood test vs colonoscopy and stool-based screening methods.
FDA Approves Deep Transcranial Magnetic Stimulation Device for MDD Treatment in Youth Ages 15 to 21, BrainsWay Announces
Deep TMS becomes first FDA-cleared brain stimulation therapy for adolescents with treatment-resistant depression and is now available for ages 15-86 for MDD treatment.
Reinterpreting WHI and Rethinking GSM: Insights from Caroline Mitchell, MD, MPH
TMS: Harvard's Caroline Mitchell, MD, MPH, questions the direction of genitourinary syndrome research priorities and reflects on FDA's removal of HRT warnings.
Autoimmune Disease Risk After HT: Clinical Insights From a Large Real-World Study
Study author Daniel Jiang, MD, PhD, discusses data linking hormone therapy to increased autoimmune disease risk in postmenopausal women and clinical implications.
New Online Tool Calculates Percentiles for 30-Year Cardiovascular Disease Risk in Younger Adults
Northwestern University unveils a groundbreaking online tool that helps younger adults understand their 30-year cardiovascular disease risk through percentile rankings.
How Neurodivergent Adults View Neurodiversity Terminology: Findings From a Large UK Survey
UK neurodivergent adults report strong views on neurodiversity terminology, emphasizing correct usage and its role in stigma, identity, and communication.
Preventive Health Inventory Boosts Diabetes and Hypertension Management Without Increasing Hospitalizations Among Veterans: New Study
A new study reveals that the Preventive Health Inventory enhances diabetes and hypertension management among veterans without increasing hospitalizations.
For GLP-1 Medication Users, Investigational NK-1 Agent May Quell GI Side Effects by Half
In the phase 2 clinical trial, tradipitant, an oral neurokinin-1 receptor antagonist, was dosed twice daily among adults with obesity and treated with semaglutide.
Chronic Pain Linked to Greater Risk of Hypertension, Depression Mediates the Relationship
Individuals who have chronic widespread pain showed a 75% increased risk of developing hypertension compared to fellow UK Biobank participants who were pain-free.
Alcohol Use at Any Level Tied to Increased Risk of Dementia: Daily Dose
Lisa Larkin, MD, on the Importance of Recognizing and Managing Vasomotor Symptoms in Menopause
Women increasingly seek evidence-based menopause care as awareness grows, yet many still suffer from untreated vasomotor symptoms.
Migraine Risk Rises With Unexpectedness of Daily Experiences, the "Surprisal" Factor
Higher surprisal scores, measuring how atypical a daily experience is, increased migraine odds by 86% at 12 hours and 115% at 24 hours in new cohort study.
FDA Accepts sNDA for Roflumilast Cream 0.3% to Treat Plaque Psoriasis in Children Aged 2 to 5 Years
FDA reviews roflumilast cream for young children with plaque psoriasis, potentially offering a first-of-its-kind topical treatment option.
Tralokinumab Looks Promising to Treat Hand Involvement in Atopic Dermatitis
LEO Pharma reveals promising 32-week results for tralokinumab, showing significant benefits for adults with moderate-to-severe hand eczema.
Use of OTC Products and Persistent Vulvovaginal Irritation in Postmenopausal Women, with Caroline Mitchell, MD, MPH
Harvard's Caroline Mitchell, MD, MPH, explains how common OTC products can worsen vulvovaginal symptoms and the importance of a targeted history in GSM care.
AI and Polygenic Risk Scores May Reshape Breast Cancer Screening Within the Decade
Donna Plecha, MD, discusses how AI-powered mammography risk prediction and polygenic risk scores will enable personalized breast cancer screening within the next decade.
Donna Plecha, MD: How to Talk to Women About Dense Breasts and Supplemental Breast Cancer Screening
Breast imaging expert, Donna Plecha, MD, provides a roadmap for primary care physicians to implement risk assessment tools and high-risk clinic referrals in their practice.
Perimenopause Misdiagnosis Affects Nearly 40% of Women as Clinicians Fail to Recognize Hormonal Transition
Nearly 40% of perimenopausal women report misdiagnosis as clinicians treat for anxiety and depression without addressing underlying hormonal imbalance.
High Ultra-Processed Food Intake Linked to Increased Risk of Early-Onset Colorectal Adenomas in Women
New research links high ultra-processed food intake to increased risk of precursors for early-onset colorectal cancer in women under 50.
Hormone Replacement Therapy After the WHI: Clinician’s Evidence Timeline (2002–2025)
The comprehensive timeline highlights how WHI findings and subsequent research reshaped HRT risk assessment, guidance, and FDA labeling through 2025.