10 States with the Lowest COVID-19 Vaccination Rates
Wyoming, Louisiana, and Oklahoma have the lowest percentage of population with shots in arms based on state population. Is your state among the other 7?
FDA Approves First Intranasal Epinephrine for Emergency Treatment of Allergic Reactions
neffy (epinephrine nasal spray) is the first alternative to epinephrine administered by autoinjector or syringe and is comparable in efficacy to the gold standard.
US 2023 Mortality Rate Drops 6% as COVID-19 Slides to 10th Leading Cause: New CDC Data
COVID-19 as a cause of death fell from the #4 spot in 2022 to #10 in 2023, which may account for some of the overall decline in the US mortality rate, suggest CDC experts.
Finerenone Phase 3 Data Show Benefit in HFpEF, Promise for New Indication
Finerenone treatment achieved a statistically significant reduction in a composite endpoint of CV death and HF events in a population not limited to CKD in T2D, Bayer announced.
HbA1c Time in Range Shows Strong, Consistent Relationship with Dementia in Older Adults with Diabetes
New study findings suggest that in older adults stable HbA1c within individualized target ranges over time may help reduce risk of Alzheimer disease and other dementias.
Monitoring Glucocorticoid Therapy in CAH: Timing, Timing, Timing
Clinical guideline recommendations for optimal timing to gauge glucocorticoid treatment effects in congenital adrenal hyperplasia require individualization. Here's why.
Treating Congenital Adrenal Hyperplasia: Challenges in the Transition to Adult Care
In young adults with congenital adrenal hyperplasia of age to transition to adult care, 25% to 50% are not successful. Here are thoughts on problems and solutions.
Lecanemab Efficacy Continues at 3 Years of Treatment for Early Alzheimer Disease
The lecanemab Clarity AD open label extension study returned no new safety signals and data reflect the therapy's disease modifying effects on key biomarkers.
HPV Vaccination Rates, Clinician Recommendations Lag at Public Health Care Facilities
HPV series initiation and completion was lower among adolescents seen at public vs private care settings and so was clinician guidance on vaccination in a new study.
Tirzepatide Reduces Risk of Heart Failure Outcomes in Adults with HFpEF and Obesity: Phase 3 SUMMIT Trial
Tirzepatide reduced the risk of severe heart failure outcomes by 38% and drove weight loss of 15.7% in adults with HFpEF and obesity, with and without T2D..
Women's Health: Best and Worst States Ranked on 32 Measures of Access, Quality, Outcomes
Maternal mortality nearly doubled between 2018 and 2022 in the US. The Commonwealth Fund ranks states on how well they care for women.
Topline PK Data Released on Self-Administered Epinephrine Sublingual Film for Severe Allergy
PK data from a self-administration study are comparable to those seen following administration by a clinician and Tmax equal at 15 minutes.
Long-Term Use of Sulfonylureas Linked to Increased Risk of Hypoglycemia Unawareness
Hypoglycemia unawareness increased over time with use of sulfonylureas but decreased with use of insulin over the same period, a new study found.
ME/CFS Rates No Different After COVID-19 Infection than After Other Acute Infection-Like Illnesses
The rate of ME/CFS was similar (3% to 4%) at 3 through 12 months for study participants who tested positive and negative for COVID-19.
Postpartum Transition Support Increases Primary Care Engagement, Reduces Risk of Readmission
Providing postpartum scheduling support increased the odds of a primary care visit within 4 months of childbirth among women with chronic disease and improved monitoring.
Semaglutide Behind Huge Increase in GLP-RA Prescriptions with Fewer Written for Type 2 Diabetes
The significant rise in new GLP-1 RA prescriptions between 2011 and 2023 saw a doubling in the proportion written for obesity and a decline in those for T2D.
Family-Wide Limit on Screen Media Use Improves Youth Mental Health: RCT Findings
Limiting screen media use to 30 minutes per day or less for all family members improved mental health measures among youth aged 4 to 17 years in this randomized trial.
Primary Care Reluctance to Treat Addiction Linked to Poor Institutional Support: New Study
Among GPs, IMs, FPs, the primary reason for reluctance to treat addiction is lack of support in the "institutional environment," followed by concerns over personal skills.
Pharmacists May be the Health Care Professionals Best Suited to Treat Hypertension
Hypertension interventions led by pharmacists and community health workers were more successful in lowering BP than those led by nurses and physicians.
Long COVID Risk Declined Over the Pandemic and Vaccination was Key, But Risk Remains
Ziyad Al-Aly, MD, and colleagues link 70% of the drop in cases to vaccine availability but caution the risk for long COVID remains significant.
Immunotherapy to Delay, Treat Type 1 Diabetes Wins FDA Fast Track Designation
The antigen-specific immunotherapy preserves endogenous insulin production via intralymphatic injection of recombinant GAD65 protein, according to Diamyd Medical.
Weight Gain in Early Adult Life Linked to Adverse Cardiac Function, Structure in Older Age
Adiposity before age 60 to 64 years, beginning as early as age 20 years, was associated with adverse cardiac structure and function not explained by current BMI.
Roche Oral Incretin Mimetic CT-966 Moves to Phase 2 Clinical Development
The oral GLP-1 RA was associated with weight loss of 7.3% in just 4 weeks and is designed with unique properties that will enhance multiple outcomes, Roche said.
Rapid Rise in Rates of Diabetes During Pregnancy in Canada Not Expected to Slow
The most concerning escalation in type 1, type 2, and gestational diabetes has been among the youngest women and girls, aged 15 to 19 years, report study authors.
Lowering Daily Sodium Intake May Reduce AF Risk in Vulnerable Adults
An analysis of 28 000 adults with vascular disease and high-risk diabetes found daily sodium intake of ≥8 g significantly increased risk for AF by 32%.
Intranasal Flu Vaccine Coadministered with High-Dose Shot More Effective in Older Adults than Shot Alone
The investigational live intranasal vaccine was safe and well-tolerated when given concomitantly with Fluzone HD and the combination outperformed the latter given by itself.
GRAIL Multicancer Early Detection Test Registrational Trials Make Good Progress, Company Says
The PATHFINDER 2 and HMS-Galleri trials are proceeding as planned with more than 175 000 participants from diverse backgrounds enrolled across both.
Novel Combination Treatment is Potent Driver of Beta Cell Proliferation in Type 1 Diabetes Model
In the mouse model of type 1 diabetes, a combined harmine/exendin-4 therapy resulted in an up to 7-fold increase in β cell numbers over 3 months, reported investigators.
Combined SGLT2i and GLP-1 RA Therapy Provides Complementary Cardiorenal Protection, According to Comprehensive Meta-Analysis
Findings from the large meta-analysis provide strong support for use of both classes to reduce CV and renal disease in adults with type 2 diabetes.
Roflumilast Cream 0.15% Approved for Treatment of Atopic Dermatitis in People Aged 6 Years and Older
The steroid-free cream was developed for long-term use and has been proven safe in an open-label extension study following successful phase 3 trials.
