Apixaban and Aspirin Appear Equal Against Recurrent Stroke in Individuals with Cardiopathy
Anticoagulation and antiplatelet therapy appeared equally effective in reducing risk of recurrent stroke following cryptogenic stroke in persons with evidence of atrial cardiopathy.
GSK RSV Vaccine Arexvy Under FDA Priority Review for Prevention of RSV in High-Risk Adults Aged 50 to 59 Years
Approval of the application would extend the current Arexvy indication for prevention of RSV in adults aged 60 years and older; a June 2024 PDUFA date is set.
Risk for a Suicide Attempt Found 8-Fold Greater in Women with PCOS
Among women with PCOS, the risk for a suicide attempt was highest (by a factor of 9) among young adults aged 20 to 40 years, followed by adolescents.
Tirzepatide Associated with "Impressive" BP Reduction in Individuals with Obesity
Mean placebo-adjusted SBP change from baseline at 36 weeks was 8.6 mm Hg in adults with obesity, according to authors of the SURMOUNT-1 ABPM substudy.
HHS Broadens Access to Medications, Treatment for Opioid Use Disorder
Access to methadone and buprenorphine treatment may be easier and incentive to continue treatment could start at home, using telehealth, according to HHS.
Combination Albuterol/Budesonide Rescue Medication for Adults with Asthma Now Available
The combination SABA/ICS inhaler is the first of its kind and treats both acute bronchoconstriction and the inflammation that drives asthma and disease exacerbation.
Among Black Women, Hypertension Before Age 30 Years May Triple Risk of Later Stroke
The 3-fold greater risk of subsequent stroke was observed in the Black Women's Health Study's youngest cohort, aged 24-34, investigators reported.
Eating Disorder Hospitalizations Rising among US Adolescents, New Study Warns
Eating disorders among US youth spiked during the COVID-19 pandemic, but a new study shows hospitalizations have been inching up for a decade or more.
Use of Cannabis Linked to High Risk of Prevalent Asthma: New Findings
Past month use of cannabis was associated with 43% greater odds of asthma than no use of the drug; odds were 2-fold greater with use of blunts.
Alcohol-Related Liver Disease May be More Deadly Among Women than Men, Study Suggests
Risk of mortality from ALD and MetALD was significantly higher among women even though both phenotypes were more prevalent among men, a new study reveals.
Investigational Nonopioid VX-548 Reduces Moderate to Severe Post-Surgical Pain in Late-Stage Clinical Trials
Oral VX-548 has the potential to fill the gap between drugs that are tolerable but lack efficacy and opioids with therapeutic efficacy but known risks, according to Vertex.
Overweight and Obesity in the US: Worst States/Best States
Overweight and obesity affect the 50 states and DC in different ways and to varying degrees but no state is unaffected. The short slide show offers insights at-a-glance.
As Measles Outbreak Persists, AAP Urges Clinicians to Ramp Up Infection Control Steps
Measles cases are reported in 6 states, which is not a surprise to one pediatrician who points to the ongoing consequences of falling vaccination rates.
Risk of Preeclampsia, Preterm Birth Prevented as Well by Low-dose Calcium as by Recommended High-Dose, Study Finds
Low-dose calcium supplementation with 500 mg/day may be as protective against poor pregnancy outcomes as the WHO-recommended dose of 1500 mg/day.
Risk for Incident Asthma and Exacerbations Increases with Atopic Dermatitis in Dose-Dependent Fashion: Study
The risk of asthma and poor outcomes was even greater among children with both conditions than among adults in this first study to compare the 2 populations.
Opioid with 'Overdose Protection' Formulation Wins FDA Breakthrough Designation
The investigational combination opioid from Ensysce Biosciences is designed to deter abuse as well as prevent accidental or intentional overdose, the company said.
More than Half of US Adults Still Don't Recognize Heart Disease as #1 Cause of Death
Heart disease has been the primary cause of death in the US for the last century, and yet 51% of adults do not recognize the fact.
Comorbid Depression and IBD Significantly Increases Risk of Hospital Readmission, Mortality, According to National Database Review
Already high rates of readmission and mortality at 30 days rose significantly higher at 90 days, according to this National Readmissions Database review.
FDA Approves Dupilumab for Eosinophilic Esophagitis in Children Aged 1 to 11 Years
Dupilumab is the first agent approved to treat EoE in this vulnerable pediatric population.
Individuals with IBD Hospitalized for COVID-19 at High Risk for Shock, Organ Injury Suggests National Analysis
Among more than 1.5 million persons hospitalized for COVID-19, a history of Crohn disease or ulcerative colitis significantly increased risk for poor outcomes.
In Crohn Disease, Biologic Dose Escalation is Common During Maintenance Phase, Study Reveals
"A meaningful percentage" of individuals with Crohn disease are treated during maintenance with biologic doses ≥20%higher than recommended in FDA labeling.
Baseline HbA1c Greater than 6.0% Linked to "Exponential" Increase in T2D Risk for Adolescents with Obesity
Adolescents with overweight or obesity and baseline HbA1c 6.3%-6.4% were at 72-fold greater risk for T2D than those with HbA1c of 5.5%, a new cohort study finds.
Contraceptive Services Must be Provided without Cost-Sharing: HHS Guidance Update
Targeting "impermissible" barriers created to no-cost contraception required by the ACA, the HHS guidance follows the Biden-Harris June 2023 Executive Order on the issue.
FDA Adds Black Box to Prolia PI Warning of Severe Hypocalcemia Risk in CKD
The Boxed Warning reflects FDA research into severe adverse events including hospitalization and death in persons with CKD treated with denosumab.
Diabetes Remission of Any Duration May Reduce Risk of Renal and Cardiovascular Disease:
Remission of T2D, regardless of duration of remission, was associated with reduced risk of diabetes-related CKD and CVD in a post hoc analysis of Look AHEAD.
Gabapentinoids May Increase Risk of Severe COPD Exacerbations, Warns New Study
In persons with COPD, use of the anticonvulsants was linked to a 39% increase in risk of severe disease exacerbation requiring hospital admission, study authors reported.
"Ozempic" and Older Adults: Awareness of & Views on Rx Medications for Weight Management
When it comes overweight, obesity, and prescription drugs for weight loss, these results from the National Poll on Healthy Aging suggest older US adults need guidance.
Bempedoic Acid Associated with 20% Reduction in Total CV Events in Prespecified CLEAR Outcomes Analysis
The protective effect of bempedoic acid appeared to increase with the number of CV events a study participant experienced, according to study authors.
Shelf-Life Extended for Narcan Nasal Spray, FDA Announces
This second shelf-life extension for the OTC naloxone hydrochloride 4 mg spray continues the FDA's campaign to prevent drug overdose and related fatalities.
Changes to the 2024 ACIP Adult Immunization Schedule: At-a-Glance
Changes to the ACIP adult schedule include new Notes on the RSV vaccines and updates to Notes on flu vaccination, COVID-19 vaccination, and the pentavalent MenB shot.