The Weekly Dose: Pediatric Vaccine Safety, Atopic Dermatitis, Dementia Risk, and Maternal Depression
Insights on atopic dermatitis treatment preferences, the safety of childhood vaccines, maternal depression’s effect on parenting, and more.
GLP-1 Medications Need a Permanent Place in Primary Care, Says Obesity Medicine Specialist
Jonathan Bonnet, MD, MPH, encourages primary care clinicians to embrace GLP-1 therapy where appropriate to stem multiple risk factors for downstream chronic diseases.
Use of Weight-Loss Drugs Increased Among US Adolescents After AAP Guideline Release
New data shows pediatric pharmacotherapy prescribing rose but remained infrequent, while nutrition counseling rates changed minimally.
Lilly's Oral GLP-1 Agonist Orforglipron Linked to Weight Reduction of 12.4% in Pivotal Phase 3 Trial
The investigational daily oral GLP-1 RA met the primary endpoint for body weight reduction at 72 weeks and also improved a range of cardiovascular risk factors.
Reframing Vaccines as Innovation: A Strategy to Rebuild Patient Trust in Primary Care
Infectious disease physician Amesh Adalja, MD, explains how PCPs can reframe vaccines as health technology to boost confidence and counter hesitancy.
Why Should Primary Care Clinicians Shift to AI-Powered Cognitive Assessment? Experts Explain
Fremanezumab Label Expanded for Treatment of Episodic Migraine in Children Aged 6 to 17 Years
Fremanezumab is now the only CGRP antagonist indicated for prevention of migraine in adults and preventive treatment of episodic migraine in pediatric patients.
11 US Vaccine Policy Updates: How Will They Affect Your Practice?
Since his senate approval as head of HHS in February, RFK Jr has enacted and/or proposed seismic changes to US vaccine policy that will impact your daily care of patients.
Investigational Antidepressant BH-200 Shows Benefit in Phase 2b Trial for MDD
The vasopressin V1b antagonist reduced depressive symptoms, with greater effects in genetically-selected patients using a precision psychiatry approach.
Nearly 17 Million US Youth Found Eligible for GLP-1 RA Therapy and Most Because of Obesity
An NHANES-based cross sectional study found that 1 in 5 of the treatment-eligible youth lacked adequate insurance and one-third had no routine place for health care.
Primary Care Needs the Right Tools to Identify MCI Early, Says Rodney Swenson, PhD
If primary care clinicians are to meet the cognitive screening demands that are growing with an aging population, they need the sharpest tools in the box, this expert says.
The Biggest Threat to Vaccine Confidence in the US: An Expert Discussion
Amesh Adalja, MD, urges physicians to use their trusted position to counter widespread vaccine misinformation and strengthen patient confidence in immunization.
Cognition is The Next Vital Sign: An Interview with David J Libon, PhD
A cognitive health assessment will soon be as routine as taking blood pressure or pulse ox, says neurocognitive researcher David J Libon, PhD. He talks more about that future.
When Guidelines Diverge: Navigating Vaccine Recommendations in 2025
Amesh Adalja, MD, advises physicians turn to specialty societies for evidence-based, reliable recommendations this respiratory virus season.
Vertex VX-993 Misses Primary Endpoint in Mid-Stage Trial, Ending Investigation for Acute Pain
The NaV1.8 ion channel inhibitor was planned as a follow-up to the company's first nonopioid for acute pain, suzetrigine, approved by the FDA in January 2025.
One-Third of US Adults Aged 45-49 Were Up-to-Date on Colorectal Cancer Screening in 2023
New data show up-to-date CRC screening rose from 20.8% in 2019 to 33.7% in 2023, with gains driven by stool testing and colonoscopy.
FIT Tests, Direct Mailed, Increase Initiation of CRC Screening in Adults Aged 45 to 49
For initiating colorectal cancer screening in average-risk young adults, a default mailed outreach strategy outperformed 3 active choice options in a randomized study.
In Testing for Cognitive Decline, It May Not Be What the Patient Says, But How It's Said That Matters
Acoustic variables, like shimmer and jitter, that are typically undetectable in human speech can be detected with tablet technology and serve as biomarkers for mental acuity.
Only 1 in 5 Women Meet Heart Health Targets at Midlife, and These 4 Factors Matter Most
Adequate sleep tops the 4 elements most important to CV health after menopause, with blood pressure, glucose levels, and smoking status close behind.
Amesh Adalja, MD, on How PCPs Can Counter Social Media Vaccine Misinformation
Amesh Adalja, MD, explains how physicians can rebut social media vaccine claims with concise, referenced facts and patient-centered communication.
Structured Lifestyle Program Yields Statistically Significant Cognitive Gains in US POINTER Trial
AAIC 2025. Structured lifestyle interventions significantly enhanced cognitive function in older adults at risk for dementia, highlighting the importance of healthy behaviors.
Brain Wave Patterns Could Serve as Biomarkers to Predict Progression from MCI to Alzheimer Disease, Novel Research Suggests
The ability to observe an early marker of Alzheimer disease progression noninvasively marks a new phase of research with potential for improved disease management.
FDA Mandates Major Changes to Opioid Labeling
The FDA requires all manufacturers of opioid pain medications to revise labeling to emphasize and explain risks with long-term use.
Ready to Prescribe a GLP-1 Medication? Please Dive Deep Into the Patient's History First, Advises John Bonnet, MD, MPH
Bonnet says a clear understanding of a patient's weight and emotional history are critical to ensure optimal use of GLP-1 therapy in a successful weight management program.
Childhood Vaccination Rates Fall Again, Exemptions Rise on Cusp of New School Year: CDC Annual Update
Only 92.5% of kindergartners received the recommended 2-shot MMR series in 2024-25 and rates were similarly low for DTaP and polio, according to the CDC.
Vaccine Hesitancy: Communication Strategies for Primary Care That Preserve Trust
Amesh Adalja, MD, infectious disease physician, outlines effective communication strategies that respect patient concerns while reinforcing physician credibility.
FDA Label Update Positions Inclisiran as First-Line Monotherapy for Hypercholesterolemia
Inclisiran can now be used without a background statin, as an adjunct to changes in diet and physical activity for reduction of LDL-C in hypercholesterolemia.
Lecanemab Shows Sustained Benefit at 4 Years in Early Alzheimer Disease: AAIC 2025
Four-year data show lecanemab slows clinical decline in early Alzheimer disease and maintains a consistent safety profile.
Tirzepatide Proves Noninferiority With Dulaglutide for MACE in Lilly's Landmark Incretin Face-Off
In the SURPASS-CVOT trial, tirzepatide reduced MACE-3 by 8% and all-cause mortality by 16% compared with dulaglutide, while also reducing HbA1c and weight.
Amesh Adalja, MD, on How to Defuse Vaccine Safety Concerns Without Derailing the Visit
Dr Adalja offers evidence-based strategies to address patient concerns about aluminum and thimerosal in vaccines.
