The Road to RSV Vaccines in the US: A Timeline Topline
Respiratory syncytial virus was deadly and untreatable across the lifespan until 2023 when the first vaccines were approved in the US. Follow the timeline, here.
HbA1c is Good for the Big Diabetes Picture but CGM is Key for the Data Close-Up
ACP 2025. The timely glucose data available with continuous glucose monitoring is what's needed for optimal daily diabetes control, says Tom Martens, MD.
Pancreatic, Colorectal Cancer Rates Rising in Young Adults Nationwide, Study Warns
The increase in pancreatic cancer among Americans aged 15 to 34 is particularly alarming and should alert clinicians to heed relevant GI symptoms as suspicious.
Patient Navigation Program Improves Colonoscopy Completion Rates After Abnormal FIT Results
The phone-based patient navigation intervention addressed barriers to CRC testing follow-up and included patient education.
Prediabetes Affects More than 97 Million Americans but 77 Million of Them Are Not Aware
The mildly elevated glycemia of prediabetes is a pathological condition with serious risks for those 77 million, says endocrinologist Samuel Dagogo-Jack, MD, DSc.
Lilly’s Oral GLP-1 Orforglipron Shows Significant and Competitive A1c and Weight Reductions in Phase 3 Trial
The positive topline data from the phase 3 ACHIEVE-1 trial suggest the small molecule GLP-1 mimetic could compete with blockbuster weekly injectables for reducing weight, A1c.
GSK: 3-Year Efficacy Data for Arexvy in Older Adults Published in Lancet Respiratory Medicine
A single dose of the RSVPreF3 demonstrated a cumulative efficacy of 62.9% against RSV-LRTD across 3 seasons in adults aged 60 years and older.
Which CRC Screening Method for Which Patient? Rachel Issaka, MD, MAS, Calls for an Honest Conversation
Issaka, from the Fred Hutch Cancer Center, said insurance coverage, a patient's resources, and social determinants of health all factor in the choice.
FDA Grants First-in-Class Marketing Authorization for Digital Therapeutic in Episodic Migraine Prevention
CT-132 is a 12-week app-based intervention that uses validated behavioral techniques to modulate labile brain circuitry involved in migraine, according to Click Therapeutics.
Emergency Care for Cannabis Use Associated with Increased Risk for Dementia in Adults: Canadian Population Study
Adults with a cannabis-related acute care visit or hospitalization were at 23% and 72% greater risk of a new dementia diagnosis within 5 years, a new study finds.
9 Common Myths About Cancer Screening and the Facts for Your Patients Who Believe Them
Myths and fears about cancer screening may be keeping some of your patients from important tests. Always ask about misconceptions, and then offer the facts.
CRC Screening Outreach Significantly Reduces Black-White Disparities, Including CRC Mortality Gap
ACP 2025: Rachel Issaka, MD, MAS, reviewed data from a Kaiser Permanente program that narrowed racial and ethnic disparities in CRC screening compliance and related deaths.
Prepregnancy Obesity, Not Pregnancy Complications, Drives Midlife Cardiovascular Risk in Women, Suggest HAPO FUS Study Findings
Gestational diabetes and hypertensive disorders of pregnancy may be markers for rather than mediators of risk for future CVD, according to new research.
Mediterranean Diet Combined with Physical Activity Mitigate Bone Density Decline in Older, At-Risk Women, New Analysis Finds
Following a Mediterranean-style diet and a prescribed regimen of physical activity was significantly protective of BMD, particularly at the lumbar level, over 3 years.
Rachel Issaka, MD, MAS: Effective CRC Prevention Programs Require Multispecialty Commitment
ACP 2025. A focused CRC prevention program begins with primary care where support and advocacy for regular screening begins, Issaka stressed.
Dexcom G7 15 Day CGM System Cleared by FDA
The extended wear benefit is augmented by the G7 15 Day CGM system's superior evidence-based accuracy, with a MARD of 8.0%
Incretin-Based Obesity Medications Show Minimal Lean Muscle Mass Loss in 6-Month Prospective Study
Loss of lean muscle mass along with fat mass is a concerning side effect of the incretin-based antiobesity medications, making the new study results encouraging.
Failure to Follow-Up After Colorectal Cancer Screening Translates into Preventable Deaths: Rachel Issaka, MD, MAS
ACP 2025: Issaka, from the Fred Hutchinson Cancer Center, told internists that three-quarters of CRC deaths can be attributed to 3 types of screening failure.
Aprocitentan Reduces BP in Black Adults with Resistant Hypertension and Lowers Proteinuria
Aprocitentan, when added to background therapy of at least 3 antihypertensive agents, led to clinically meaningful and sustained BP reduction in this preplanned subanalysis.
Second Measles-Related Death in a Child Reported in Texas as US Cases Surpass 600
As the US measles outbreak tops 600 cases, Texas reported a second child's death in a young girl who was unvaccinated and had no underlying health conditions.
Primary Care Primer for Headache Management, with Morris Levin, MD
ACP 2025. The director of the UCSF Headache Center built an evidence-based framework for diagnosing and treating headache disorders seen in primary care.
Eisai Presents Real-World Lecanemab Data at AD/PD 2025 Confirming Phase 3 Clinical Trial Findings
In addition to support for phase 3 CLARITY AD findings, new evidence was presented supporting lecanemab safety and efficacy in ApoE ε4 carriers and non-carriers.
Alphyn Biologics Initiates Phase 2b Trial of Botanical Drug for Atopic Dermatitis
The investigational botanical zabalafin hydrogel has shown antipruritic, antibacterial, and anti-inflammatory properties, addressing the multifactorial nature of AD.
ASCVD in Women is Different: A Review of Pathophysiology, Risk Factors, Presentation
ACP 2025. Karol E Watson, MD, PhD, highlighted how traditional approaches to CV care have poorly addressed the unique presentations, risk factors, and pathophysiology of heart disease in women.
CVD Prevention in Older Adults: Crucial and Also Controversial
ACP 2025. Harvard gerontologist and preventive cardiologist Ariela Orkaby, MD, MPH, highlighted the many nuances required in the cardiovascular care of the aging population.
Racial and Ethnic Disparities in Pediatric Atopic Dermatitis Prevalence and Care are Persistent and Significant: New Scoping Review
Black children were 2.4 to 4.1 times more likely to experience early-onset and persistent disease than White peers and much more likely to require urgent care for their AD.
Trontinemab: Roche Announces Phase 3 Development Program for the mAb in Adults with Early Alzheimer Disease
Using the proprietary Roche Brainshuttle technology, trontinemab leads to deep, rapid amyloid plaque reduction with a favorable safety profile.
"Allergic to Everything"
ACP 2025. Scripps Clinic's John M Kelso, MD, offered topline updates on all types of allergies including a step-by-step on how to "delabel" patients identified as penicillin-allergic.
Peripheral Arterial Disease in the US: Amputation is Not the Answer
Foluso A. Fakorede, MD, sketched a disturbing picture of recognition and management of PAD in the US, highlighting stark racial and ethnic disparities and making an urgent call to action.
Colorectal Cancer Screening in 2025: Disparities Remain Persistent and Significant
The highest CRC mortality rates occur at the “intersection of race, place, and class," Rachel Issaka, MD, MAS, told internal medicine clinicians at the annual ACP meeting.