What, Exactly, is an Alcoholic Drink-equivalent?
The shapes, sizes, and content of a US alcoholic drink-equivalent vary widely. Get a quick educational summary of the variety and more data that may help in your daily clinical practice.
Friday's 5 Quotes for Primary Care 4-14-2023
Clopidogrel bests aspirin for post-PCI monotherapy; metabolic dysfunction predicts HCC in post-HCV fibrosis; brain signatures may help focus obesity treatment for the sexes, and 2 more studies of note.
Increase in Barriers to Reproductive Health Care Seen Disproportionately Among Historically Disadvantaged
Survey respondents facing the greatest increase in barriers to desired care were aged 25 to 29 years, identified as Hispanic, and lived below 100% of the federal poverty level.
Juul Labs Makes Largest Settlement to Date with 6 States, DC, for Role in Youth Vaping Epidemic
The $462 million monetary penalty is accompanied “the most stringent restrictions” on how the company markets, sells, and distributes its products.
Clopidogrel Superior to Aspirin for Long-term Antiplatelet Monotherapy After PCI
Metabolic Dysfunction May Better Predict Risk for HCC in Persons Cured of HCV with Advanced Fibrosis
A population-based study found metabolic dysfunction more prevalent than ultrasonographic steatosis in patients recovered from HCV and a better predictive tool for disease progression.
FDA Fast Tracks Ensitrelvir, Investigational Antiviral Targeting SARS-CoV-2 Replication
Ensitrelvir fast track status is supported by phase 3 study findings showing resolution of COVID-19 symptoms a full day earlier in those taking the drug vs placebo.
Research on Pain Management for Persons with COPD Insufficient, Flawed
Pain is a prominent symptom among persons with COPD yet management is not included in clinical guidelines and current research findings are vague, say study authors.
Friday's 5 Quotes for Primary Care - 4-7-2023
High salt intake linked to coronary atherosclerosis; daily ETOH, even in small doses, is dangerous; statins don't increase muscle injury; and 2 more studies of note.
6 Biologics for Severe Asthma, 3 Essential Facts on Each
For each of the 6 biologic agents FDA-approved for severe asthma, find the mechanism of action, indication, and biomarkers that predict enhanced response.
What, Exactly, is Alcohol Use Disorder?
AUD affects 15 million Americans, with men nearly 2 times more vulnerable to the disease vs women. Are you tracking signs and symptoms in your patients?
RSV Circulation Approximating Prepandemic Seasonality, Suggest New CDC Data
Onset of the 2022-2023 RSV season and its end were closer to historical patterns but atypical circulation may continue, say researchers writing in MMWR.
Daily Alcohol Intake Appears More Dangerous than Not, Even in Small Doses and Particularly for Women
Results of previous studies supporting health benefits of low-dose, moderate drinking were likely skewed by bias and confounding, say authors of a new meta-analysis.
Cluster Headache, Migraine Show Strong Links to the Circadian System: Meta-analysis
Cluster headache and migraine are described as "highly circadian at multiple levels," suggesting hypothalamus involvement and potential for new treatments, study authors say.
Sodium Intake Shows Strong Linear Relationship with Risk of Both Carotid and Coronary Atherosclerosis: Population-based Study
Each 1000 mg rise in Na excretion saw a corresponding 3%, 4%, and 4% higher risk of worsening carotid plaque, CAC score, and coronary artery stenosis, respectively.
Comparative Efficacy, Safety of Analgesics to Treat Acute Low Back Pain Questioned
Meta-analysis authors urge caution in use of analgesics used commonly to treat non-specific acute LBP in the absence of head-to-head RCT evaluating both efficacy and safety.
Multisite Chronic Pain Increases Dementia Risk, Hippocampal Injury: UK Biobank Analysis
The risk of neurocognitive abnormality increased with each additional pain site among patients with multisite chronic pain and appeared to be mediated by loss of hippocampal volume.
FDA Requires Opioid Manufacturers to Provide Mail-back Envelopes to Accompany Prescriptions
Opioid manufacturers will supply outpatient pharmacies and other dispensers with pre-paid mail-back envelopes for disposal of unused medication.
Use of Medical Cannabis May Reduce Reliance on Opioids to Manage Chronic Pain: Survey Findings
Use of medical cannabis for chronic pain management is leading to decreased use of opioid analgesics and other common interventions, suggest new survey findings.
Online E-health Program Reduces Daily Opioid Use, Improves Pain Scores vs Usual Care
Patients on long-term opioid therapy for chronic pain who used the e-health program for 4 months reported cutting back on opioids as well as improved pain scores.
Friday's 5 Quotes for Primary Care 3-31-2023
Screening for diabetes by weight will increase diagnoses; weight regain after loss doesn't cancel health benefits; strategy tested to improve RSV detection; and 2 more studies of note.
Mediterranean, Low-fat Diets May Reduce Death, CV Events in Patients at Increased Risk
The Mediterranean and low-fat dietary patterns were the only 2 out of 7 "structured, named" programs shown to reduce risk of mortality, CV events in persons at risk.
Rx for US Health Care Inequity: Increased Access to Primary Care
An ongoing relationship with a primary care clinician is foundational to personal and community health and adults of color are less likely than White adults to have that.
Reversing Prediabetes Without Lifestyle Change May Not Reduce Mortality Risk: Study
Among persons with prediabetes who reverted to normoglycemia, only those who remained physically active saw a reduced risk of all-cause death, study authors report.
Health Equity Has it's Roots in the Exam Room, says AAFP President Iroku-Malize
Family physicians are positioned to identify at the patient level specific factors that contribute to and sustain disparities in health and US health care, says AAFP president.
Weight Regain May Not Fully Diminish Benefits of Weight Loss on Cardiometabolic Health
A new study examines the legacy effects of weight loss on cardiometabolic disease risk factors, finding benefits persist up to 5 years, despite weight regain.
Screening for Diabetes by Age vs by Weight Could Reduce US Health Disparities, Suggests a New Study
The disproportionate prevalence of undiagnosed diabetes among racial/ethnic minorities in the US begs for a new screening paradigm; this may be the one.
AAFP President: We Need to Go Forward, Not Backward, on Racial Disparities in Health Care
Disparities in US health and health care delivery along some dimensions are moving backward, not forward, says AAFP president Iroku-Malize in this interview.
Best & Worst States for Physicians: 2023 Snapshot
Get a quick look at the 5 states ranking highest and lowest on metrics including wages, competition, state medical board punishment, cost of malpractice insurance, and size of malpractice payout.
Daily Dose: Statin-Eligible Minority Patients Sorely Undertreated
A daily dose of clinical news you may have missed.