Editor of Patient Care Online.
Head-To-Head Trial Shows Dynavax’s Z-1018 Rivals Shingrix for Efficacy and Tolerability
Z-1018, which combines a glycoprotein E (gE) antigen and proprietary adjuvant, was evaluated in adults aged 50 to 69 and the 100 µg dose will advance to part 2 of the trial.
Excess Intake of Ultraprocessed Foods Tied to Higher Cardiometabolic Risk: Daily Dose
Your daily dose of the clinical news you may have missed.
Obesity and Venous Disease: Risk Factors and Key Diagnostic Challenges
Shagun Bindlish, MD, board member of the American Diabetes Association, discusses challenges to diagnosing and treating venous disease in patients with obesity.
Atumelnant for Congenital Adrenal Hyperplasia Agent Granted FDA Orphan Drug Designation
The FDA's ODD award is based on the positive findings from the phase 2 TouCAHn trial, which also support Crinetics' robust phase 3 pivotal clinical trial program for the novel agent.
Vaginal Estradiol Not Linked to Recurrent Ischemic Stroke in Women With Prior Stroke
Vaginal estradiol is often prescribed as first-line therapy for genitourinary syndrome of menopause, making the findings supportive of current clinical practice.
Use of Digital Twin Technology Enabled Significant HbA1c Reduction and Medication Tapering in Primary Care T2D Management
A Cleveland Clinic trial revealed that AI-driven precision treatment significantly reduced HbA1c and body weight, often eliminating need for medications other than metformin.
Mailed FIT Kits Boost CRC Screening at Ages 45–49: Daily Dose
Risk of Major Depressive Disorder Spikes Following a Medical Diagnosis, Endures for Decades: New Data
The risk for MDD is greatest in the first month after diagnosis and the absolute risk remains elevated even 20 years later, making early detection and treatment imperative.
First Oral Penem Antibiotic Now Available in the US for Uncomplicated UTIs
The first oral penem antibiotic, Orlynvah™, has launched in the US, offering a vital treatment option for women with resistant uncomplicated UTIs.
The Weekly Dose: Nutrition Gaps, Tau Pathology in Mood Disorders, RSV Protection, and More
This week’s roundup covers nutrition counseling barriers, tau pathology in mood disorders, RSV protection, AD patient needs, and a new Shingrix syringe.
How to Talk to Patients About Respiratory Virus Vaccines This Year? The Same Way We Always Do
William Schaffner, MD, advises first and foremost to stay away from politics, to acknowledge and normalize patient fear and concern, and to answer quickly and with confidence.
Long-Term Obesity Associated With Accelerated Biological Aging in Young Adults
A recent study showed obesity in childhood or adolescence accelerates biological aging by up to 48% in young adults.
OTC Contraception Option Improves Access For Women at High Risk for Unintended Pregnancy
Opill OTC has significantly increased contraceptive use and shifts from less effective options among women who are uninsured, of racial/ethnic minorities, and live in the rural US.
Fewer Than 1 in 4 Women Maintain Optimal CV Health in Menopause: Daily Dose
Back-to-School Pediatric Vaccination: A Family Physician’s Perspective on Boosting Rates, Countering Misinformation
Sarah Sams, MD, emphasizes education, empathy, and proactive communication to support families and protect public health.
Can Hearing Aids Reduce Risk for Dementia? If They Are Implemented Early, a New Study Suggests
Risk of dementia was more than 60% lower among adults aged 60 to 69 years with hearing loss who used hearing aids in the first study to highlight early intervention.
Shifts in CDC Policy on COVID-19 Vaccination for Children Dilute Protection for the Vulnerable Population, ID Specialist Warns
William Schaffner, MD, ID specialist and vaccine expert, advises following state guidance on back-to-school shots and thinking through new guidance on COVID shots for kids.
Improvements in Hidradenitis Suppurativa Observed During Treatment with GLP-1 Receptor Agonists
The statistically significant improvements seen in key HS symptoms during GLP-1 treatment for obesity suggest overlap in both mechanistic and immunologic effects.
Public Awareness of HPV and HPV Vaccine Remains Low, Especially in Midwest and South, Study Finds
New data show more than one-third of US adults are unaware of HPV or the HPV vaccine, with gaps greatest in the Midwest and South, where HPV-related cancers are most common.
Viking's Oral Dual Incretin Agonist VK2735 Produces Up to 12% Weight Loss at 13 Weeks in Midstage Trial
The GLP-1/GIP receptor agonist also showed promise in an exploratory maintenance arm, producing rapid weight loss at an induction dose that was sustained after down-titration.
GLP-1 Eligibility High Among US Youth, but Insurance Gaps Limit Access: Daily Dose
Vaccine Policy Shifts, Public Trust, and Countering Misinformation
Infectious disease expert Amesh Adalja, MD, discusses new vaccine policies, misinformation, and how PCPs can build confidence during National Immunization Awareness Month.
Preparing for the 2025-26 Respiratory Virus Season: A Q&A With Sarah Sams, MD
Family physician Sarah Sams, MD, shares practical strategies on vaccine updates, coadministration, and addressing hesitancy this respiratory season.
Investigational Psychedelic RE104 for Postpartum Depression Delivers Positive Phase 2 Results: Reunion Neuroscience Update
In the RE104 group receiving the 30-mg dose, clinically meaningful reductions in the primary endpoint were seen on day 1 posttreatment and sustained through day 28 follow-up.
FluMist Intranasal Flu Vaccine Now Available for At-Home Delivery and Self-Administration
AstraZeneca launches FluMist Home, the first FDA-approved at-home flu vaccine service, allowing self- or caregiver administration of the intranasal influenza vaccine for the 2025–26 season.
Pharmacy-Based FIT Distribution Could Broaden CRC Screening, But Results Must be Delivered with Care, New Survey Reveals
If FIT results indicated colonoscopy, respondents preferred personal follow-up vs digital; significant barriers to undergoing fear of the test and positive cancer finding were the most significant barriers to follow-up.
More US Adults in Their 40s Undergoing CRC Screening After Age Threshold Lowered: Daily Dose
AHA/ACC Release Revised Hypertension Clinical Practice Guideline to Reduce CVD Risk
Updates to the 2017 guideline focus on new monitoring strategies, earlier intervention to reduce cognitive decline, improved perinatal care, and refined risk assessment.
The Weekly Dose: New Endocrine Guidelines, Digital Asthma Gains, AI Trust Gap, GLP-1 & Dementia Risk, First CHE Treatment
Explore the latest insights on diabetes in pregnancy, asthma management disparities, AI in health care, dementia risk reduction, and new eczema treatments.
COVID-19 Infection Raises Risk of Asthma and Other Respiratory Type-2 Inflammatory Diseases
Large US cohort study finds COVID-19 infection increases short-term risk of asthma, allergic rhinitis, and chronic rhinosinusitis, while vaccination lowers these risks.
