PCP Visits Associated with Smoking Cessation after Lung Cancer Diagnosis and Before Surgery
CHEST 2021: Among >7000 veterans diagnosed with lung cancer and scheduled for surgery, seeing a primary care doctor was linked to pre-operative quitting.
Biologics Reduce Severe Asthma Exacerbations in Real-world Study of Vulnerable Patients
CHEST2021: The CHRONICLE study of biologics to treat severe asthma found reductions in exacerbations of more than 50% in patient groups not included in clinical trials.
FDA Advisory Panel Supports Moderna, J&J COVID Boosters in Back-to-Back Votes
The Vaccines and Related Biological Products Advisory Committee unanimously recommended the Moderna booster on Thurday, the J&J booster on Friday.
Less than Half of Vulnerable Older Adults Monitor BP at Home
A survey of adults aged 50-80 years with hypertension and/ or related comorbidities found even among those with a BP monitor at home, less than 50% checked BP at least once a week.
Inappropriate Patient Requests: How do you Get to No?
Fielding inappropriate patient requests and getting to "No" while preserving rapport with a patient is an essential clinical skill. AAFP has a 5-step approach.
USPSTF Shift: Aspirin Use for Primary CVD Prevention Carries Greater Risk, Less Benefit
The USPSTF shift to a more conservative recommendation on use of aspirin compared to its 2016 stance is based on new RCT data and net benefit modeling.
Phase 3 Trial Shows AZ Antibody Combination Reduces Risk of Severe COVID-19, Death in High Risk Groups
The long acting antibody combination reduced risk of severe disease or all-cause mortality by 50% in outpatients with high-risk comorbidities.
Iron Deficiency Increases Risk for Incident Coronary Heart Disease in Middle Age, Suggests New Study
Iron deficiency can't be causally linked to CHD yet, but evidence is accumulating for the association, according to authors of a new European study.
WHO Makes Historic Recommendation for Distribution of Malaria Vaccine
WHO endorsement for widespread use in Africa of the only vaccine against malaria comes at a time when progress in control of the disease has "stalled," the organization says.
Two-dose Pfizer Vaccine Protects Against COVID-19 Hospitalization for at Least 6 Months
Two doses of the Pfizer COVID-19 vaccine also showed sustained efficacy of 93% against Delta-related hospital admission.
For BP Monitoring, Patients Prefer Home over Clinic, Kiosk, or 24-hour Ambulatory
Clinical guidelines recommend home or ambulatory BP monitoring to diagnose hypertension. New research sheds light on what patients prefer and will adhere to.
Atrial Fibrillation Detected by ICD Linked to Ischemic Stroke within 5 Days
The temporal connection of atrial fibrillation and risk of ischemic stroke provides support for short-duration oral anticoagulation, said study authors.
Janssen RSV Vaccine for Older Adults Drives Robust Cellular Immune, Humoral Response
Janssen's investigational vaccine showed efficacy of up to 80% in preventing RSV-mediated lower respiratory tract infections in older adults.
Uncontrolled Hypertension More Likely in Younger Men, Older Women, Study Finds
Hypertension in women over age 70 years and men younger than 50 years requires closer monitoring, even if patients are on treatment, say authors.
FDA Approves Oral CGRP Inhibitor Atogepant for Prevention of Episodic Migraine
The daily oral CGRP inhibitor is the only agent in the class developed specifically for prevention vs acute treatment of episodic migraine.
Merck Oral Antiviral Reduces by Half the Risk of COVID-19 Hospitalization, Death in Vulnerable Adults
The positive results of the Merck MOVe-OUT phase 3 interim analysis of molnupiravir have led to an early halt to study recruitment, the company said Friday.
People Living with HIV Use Fewer Essential Clinical Services and Less Frequently During Pandemic
Viral-load monitoring rates decreased and clinic visits declined overall despite an increase in use of telehealth.
CDI-specific Follow-up Visits Rare among Patients Hospitalized for Recurrence
IDWeek 2021: A new study found that only 16% of patients with CDI rehospitalized for recurrent infection had been seen in follow-up 30 days after original discharge.
SUSTAIN-10 Post-hoc Analysis Suggests Additive Benefits for GLP-1 RA-SGLT-2i Combination
This post-hoc analysis showed increased reductions in A1c, weight, and BP in T2D patients prescribed GLP-1 receptor agonists who were already taking an SGLT-2 inhibitor.
Reverse-dipping BP, Heart Rate Variability Linked to Increased All-cause Mortality in Diabetes
A pattern of nocturnal reverse-dipping blood pressure in persons with type 1 or 2 diabetes put them at more than twice the risk of all-cause mortality, according to new research.
IDWeek 2021: C diff Clinical Outcomes Unchanged after 2017 IDSA Guideline Update
IDWeek 2021: Use of vancomycin vs metronidazole increased after the 2017 IDSA recommendation but CDI recurrence rates increased slightly, investigators report.
Sustained Weight Loss May Reverse CV Risk Factors Linked to Obesity, Study Shows
EASD 2021: For persons who have had obesity, returning to a healthy weight may reduce risk for hypertension and dyslipidemia, and modestly for diabetes.
Women with T2D Less Likely to Receive Guideline-recommended Cardiovascular Care vs Men
EASD 2021: Women with type 2 diabetes were less likely to meet targets for CV risk management vs men but at lower risk for future CV events, a new study found.
H Pylori Independently Associated with Carotid Plaque Formation, Investigators Find
Helicobacter pylori infection in early-middle-aged adults was associated with higher BMI, triglyceride levels, carotid plaque formation, and carotid intima-media thickness.
Early LDL-C Exposure and Cumulative Burden Increase CHD Risk in Middle Age
Clinical decisions on LDL-C management currently rely on a measure at one time point, typically middle age. A new study suggests burden begins early and so should assessment.
The State of American Obesity 2021
More than half of adults in every US state had either overweight or obesity in 2020. This at-a-glance slide show reports more findings from an annual compilation of public data.
FDA Authorizes Pfizer-BioNTech COVID-19 Vaccine Booster for Select Groups
The Pfizer-BioNTech booster shot is authorized for use in persons aged ≥65 years, at high risk of severe disease, and who have frequent exposure to the virus increasing risk for severe infection.
10 States with Largest COVID-19 Case Increases in the Last 7 Days
COVID-19 case increases in the past 7 days range from 100% to 3.16% among the 10 states with the most significant rises. Is your state among these?
J&J Preprint Data Show Real-world Durability, Promise for Booster Shot Against COVID-19
Strong evidence from a large, real-world evidence study, and preliminary data from a phase 3 booster-dose trial may support J&J's next steps toward FDA authorization of a COVID-19 booster.
Pfizer-BioNTech Report COVID-19 Vaccine is Safe, Effective in Children Aged 5 to 11 Years
Pfizer/BioNTech report "robust" antibody response to COVID-19 vaccine in children aged 5 to 11 years with safety profile comparable to that seen in persons aged 16 to 25 years.
