January 16th 2025
The agency estimates that limiting nicotine levels could lead to 1.8 million fewer tobacco-related deaths by 2060 and health care savings of $1.1 trillion a year over the next 40 years.
January 13th 2025
The planned Phase 2 trial in IPF will focus on assessing MTX-463’s safety, pharmacokinetics, and efficacy.
January 8th 2025
The FDA approved the addition of Guillain-Barré syndrome warnings for Abrysvo and Arexvy, citing postmarketing data suggesting an increased risk.
December 18th 2024
The 2 novel vaccine candidates each combine a Sanofi licensed influenza vaccine with the Novavax adjuvanted recombinant COVID-19 vaccine.
Your daily dose of the clinical news you may have missed.
Phase 3 Trial Shows AZ Antibody Combination Reduces Risk of Severe COVID-19, Death in High Risk Groups
The long acting antibody combination reduced risk of severe disease or all-cause mortality by 50% in outpatients with high-risk comorbidities.
Two-dose Pfizer Vaccine Protects Against COVID-19 Hospitalization for at Least 6 Months
Two doses of the Pfizer COVID-19 vaccine also showed sustained efficacy of 93% against Delta-related hospital admission.
Janssen RSV Vaccine for Older Adults Drives Robust Cellular Immune, Humoral Response
Janssen's investigational vaccine showed efficacy of up to 80% in preventing RSV-mediated lower respiratory tract infections in older adults.
10 States with Largest COVID-19 Case Increases in the Last 7 Days
COVID-19 case increases in the past 7 days range from 100% to 3.16% among the 10 states with the most significant rises. Is your state among these?
Fixed-dose Albuterol/Budesonide Superior to Components for Asthma in Dual Phase 3 Trials
The albuterol/budesonide combination significantly reduced the risk of severe exacerbations and improved lung function in mild-to-moderate asthma.
Ivermectin Insanity
Ivermectin has shown no clinical benefit for the many viral infections it has been studied in - including COVID-19. Why are patients buying it and physicians prescribing it?
Smoking, NSAID-exacerbated Respiratory Disease Among Risk Factors for Severe Asthma Identified in New Study
A new study found several risk factors associated with severe adult-onset asthma, including smoking, NSAID-exacerbated respiratory disease, and sibling count.
Mezopelumab Approved by FDA for Chronic Rhinosinusitis with Nasal Polyps
FDA approval of mezopelumab follows the phase 3 SYNAPSE trial in which the anti-Il-5 monoclonal antibody reduced by 57% the need for nasal polyp surgery.
FDA Accepts Tezepelumab Biologics License Application and Grants Priority Review
Tezepelumab, a novel human monoclonal antibody that shows promise to reduce exacerbations across asthma phenotypes, was granted FDA Priority Review.
The Tobacco Endgame: 4 Major Cardiology Societies Press World Governments to Act
Four major cardiology organizations stand behind increased government action to eradicate tobacco use worldwide. Click here for a summary of why, why now, and how.
ATS.2021: Tezepelumab Significantly Reduced Asthma Exacerbations Requiring Hospitalization in Phase 3 NAVIGATOR Trial
Extended Exposure to Air Pollution Raises Hospitalization Risk in COVID-19 Patients with Pre-existing Respiratory Diseases
Patients with asthma or COPD living in areas with high levels of air pollution are at an increased risk of hospitalization if they contract COVID-19, suggests a new pilot study.
Flu Shot May Protect Against COVID-19, Reduce Severity, Study Finds
Individuals vaccinated against influenza were 24% less likely to be infected with COVID-19 than those who did not get the flu shot, according to Michigan Medicine researchers.
Biologic Therapy for Asthma & COPD: 8 Questions on Targets, Pathways, & mAbs
Research into biologic therapy for asthma and COPD has been both successful and frustrating. Find out what you know about the progress with these 8 questions.
Chronic Diseases in Multimorbidity May Share Origins, Study Finds
Using metabolomic profiling from more than 11 000 individuals, researchers identified common pathways linking seemingly unrelated diseases that often co-occur.
COPD Outcomes Improve with Triple Therapy, Regardless of Exacerbation History
Post-hoc analysis of the phase 3 KRONOS study concluded that the benefits in COPD exacerbation seen were not driven by the small subgroup with a prior history of exacerbations.
Are Biologics for COPD Around the Corner? A Quick Look at the Literature
No biologic agent is approved to treat COPD, but progress is being made. Key developments of the past few years are summarized in this brief slideshow.
Hyaluronan Improves Respiratory Failure in Acute Exacerbation of COPD
Hyaluronan represents a new class of biologic that significantly improves lung health in patients with severe COPD.
COPD Diagnosis in Primary Care: 6 Essential Facts
Most diagnoses of COPD are made in the primary care setting. Try these 6 questions to see what you know about the essentials of the differential diagnosis.
Asthma, COPD, & Asthma-COPD Overlap: A Quiz in Differential Diagnostics
Distinguishing asthma and COPD can at times be problematic and the asthma-COPD overlap picture is even less clear. Check your recall of GINA/GOLD guidelines on all 3.
Passive Smoke Exposure in Childhood May Cause Subclinical LV Dysfunction in Adults
AHA 2020 Virtual Scientific Sessions: Cumulative exposure, exposure intensity, and number of household smokers in childhood all impact adult heart function, study authors found.
Tezepelumab for Severe Asthma Meets Phase 3 Primary Endpoint
The novel monoclonal antibody could bring relief to millions of persons with severe, uncontrolled asthma, including those with a low eosinophil phenotype.
COPD Self-management App Reduces Exacerbations, Readmissions vs Usual Care
Use of the myCOPD app after hospitalization for acute COPD exacerbation reduced subsequent exacerbations by nearly 50%, according to study authors.
CVD Mortality in COPD Related to Factors Other than Lung Function Decline
In COPD patients, a new study found no association between lung function decline and individual CVD outcomes, but disease exacerbations and dyspnea were implicated.
Genetic Mutations May Underlie Severe COVID-19 Illness
More than 10% of those who develop severe COVID-19 have misguided antibodies that derail the immune response, according to new research.
Asthma: Long-acting Muscarinic Antagonists Overused, Up Exacerbation Risk
Long-acting muscarinic antagonists, recommended as add-on therapy for asthma, are too often used as monotherapy and are linked with severe exacerbations, a new study finds.
“Social Smoking” Linked to Disproportionately High Risk of Death from Lung Disease, Lung Cancer
New research presented at the virtual European Respiratory Society International Congress showed "social smokers" are more than twice as likely to die of lung disease vs non-smokers.
NIH COVID-19 Treatment Guidelines Updated Based on New Data
Treatment guidelines on COVID-19 from the NIH were updated today based on data from clinical trials of hydroxychloroquine, ivermectin, and IL-6 inhibitors.
ACIP Revises Adult Pneumococcal Vaccination Recommendations: Good, Bad, and Ugly
The ACIP, once more, revised its recommendations for administration of pneumococcal vaccination among adults aged ≥65 years. Is there a lesson learned here?
US Adolescent E-cigarette Users at Increased Risk for COVID-19
A new survey found adolescents who have ever used e-cigarettes are 5-times more likely to receive a COVID-19 diagnosis. More results at-a-glance in our new slideshow.