January 16th 2025
The agency estimates that limiting nicotine levels could lead to 1.8 million fewer tobacco-related deaths by 2060 and health care savings of $1.1 trillion a year over the next 40 years.
January 13th 2025
The planned Phase 2 trial in IPF will focus on assessing MTX-463’s safety, pharmacokinetics, and efficacy.
January 8th 2025
The FDA approved the addition of Guillain-Barré syndrome warnings for Abrysvo and Arexvy, citing postmarketing data suggesting an increased risk.
December 18th 2024
The 2 novel vaccine candidates each combine a Sanofi licensed influenza vaccine with the Novavax adjuvanted recombinant COVID-19 vaccine.
Your daily dose of the clinical news you may have missed.
Daily Dose: Hospitalization for COVID-19 vs for Flu Linked to More Long-Term Outcomes
Two RSV Vaccines, One Savvy Patient who Asks, "Which One do You Recommend?"
RSV vaccines from Pfizer-BioNTech and Moderna for adults aged 60 years and older aren't that different, so which would you recommend if a patient asks?
COPD Exacerbations May Increase Risk of Severe CV Events by More Than 15-Fold: Cohort Study
The risk of severe CV events, including leading to death, was greatest in the first week following an exacerbation but remained significantly elevated 1 year later.
Daily Dose: Higher Omega-3 Fatty Acid Intake May Slow Pulmonary Fibrosis Disease Progression
Hospitalization for COVID-19 vs for Influenza Linked to More, More Severe Long-Term Outcomes: Study
After hospital discharge, persons who had COVID-19 remained at greater risk of death and myriad adverse health outcomes compared with those who had seasonal flu.
Moderna mRNA RSV Vaccine for Adults Returns Positive Phase 3 Results
Moderna's investigational vaccine against RSV in adults showed mean efficacy of 83% against the infection and is the only mRNA technology-based RSV shot.
EPA, DHA May Have Protective Effects in Pulmonary Fibrosis
Higher serum levels of the omega-3 fatty acids were associated with slowed disease progression and longer transplant-free survival in a new study.
FDA Grants Priority Review to Merck BLA for Investigational 21-Valent Pneumococcal Vaccine
If approved the 21-valent shot would be the first pneumococcal conjugate vaccine indicated specifically for adults.
Daily Dose: Coadministration of RSV and Influenza Vaccines
Coadministration of RSV, Influenza Vaccines Found Safe and Effective in New Study
The coadministration of RSVpreF and seasonal influenza vaccine was found to generate robust immune responses in older adults, reported authors of new study.
Paxlovid Associated with Virologic Rebound in One in Five Patients with Severe COVID-19 Infection
The finding implies the potential for virus transmission after initial recovery from the infection, according to study authors.
CDC Core Elements of Outpatient Antibiotic Stewardship: The Quiz
According to the US CDC, the most important modifiable risk factor for antibiotic resistance is (fill in this blank). Find out here and fill in 5 more blanks.
Daily Dose: Global Disparities in Asthma Prevalence
Daily Dose: Variation in Post-ED Follow-Up Visits for Acute Bronchiolitis Across US States
Low Estimated Burden of Asthma in Low- and Middle-Income Countries Likely Reflects Underdiagnosis, Underreporting
A new meta-analysis found prevalence of asthma higher in countries with better air quality, higher income status, and health care access.
Post-ED Discharge Follow-up Visit for Acute Bronchiolitis Linked to Subsequent Hospital Admission
Infants who attended a recommended follow-up clinic visit after being seen in an ED were also slightly more likely to receive medications outside of guideline recommendations.
Hydrocortisone Bests Other Corticosteroids for Community-Acquired Pneumonia in New Analysis
Data presented at CHEST 2023 shows treatment with hydrocortisone is associated with a decrease in morality among patients with community-acquired pneumonia.
Daily Dose: Social Risk Factors for RSV Hospitalization in Older Adults
7 New Approved Drugs for Primary Care: Q3 2023
First nonprescription daily oral contraceptive pill, OTC opioid antagonist nasal spray for opioid overdose, and 5 more FDA-approved drugs primary care clinicians should know about.
Daily Dose: Coadministration of RSV and Flu Vaccines in Older Adults
Daily Dose: Maintenance Therapy Utilization Suboptimal Before Asthma Exacerbations
IDWeek 2023: Nirsevimab Efficacy Against RSV-LRTI-Associated Hospitalization is Robust Across Infant Subgroups
IDWeek 2023. Nirsevimab efficacy was significant across infant subgroups in preventing hospitalization for RSV-LRTI during a first RSV season.
IDWeek 2023: Social Determinants of RSV Hospitalization in Older Adults
IDWeek 2023: Older adults hospitalized with respiratory syncytial virus were more likely to be women, be immunocompromised, and to have traveled within the prior 2 weeks,
IDWeek 2023 Late Breaker: Efficacy of Single RSVPreF3 Dose Sustained Over 2 Seasons in High-Risk Older Adults
A phase 3 study found VE from a single shot against RSV-LRTD in adults aged ≥60 years persisted through a second season; revaccination did not increase protection.
Coadministration of RSV, Influenza Vaccines is Safe and Effective in Older Adults, Study Finds
Immune response in older adults after receiving both vaccines in the same visit was noninferior to sequential administration and the safety profile was acceptable.
Late-Breaker: COVID-19 mRNA-1273 Booster Most Effective Among Adults Aged 65 and Older During Delta, Omicron Surges
The study findings on enhanced immunity from a third mRNA-1273 dose and specific population benefits will help build effective public health policy, authors say.
Breaking: Novel Live-Attenuated Intranasal COVID-19 Vaccine Yields Significant Humoral, Cellular Immune Response
The intranasal delivery and live attenuated form of CoviLiv may strengthen immune response and vaccine acceptance and uptake in populations and regions where both are low.
IDWeek 2023: Tripledemic Viruses Under the Microscope
COVID-19, influenza, and RSV will be the topics of a different types of sessions examining the history, new diagnostics, prevention, and future treatments during IDWeek 2023.
Use of Maintenance Therapy Suboptimal Before Asthma Exacerbations, New Research Finds
Many patients with moderate-to-severe asthma may not be using inhaled corticosteroids along with rescue medications to avoid serious disease exacerbations.
Influenza Rx in Practice: Which Antiviral Makes Sense?
Influenza B is the diagnosis and the patient wants to start antiviral therapy. Factoring in CDC guidance, patient preference, and price, which of the 4 options makes most sense?