2025 AAD Atopic Dermatitis Update: Linda Stein Gold, MD, on New Topical and Biologic Therapies
Linda Stein Gold, MD, reviews AAD’s 2025 updates on new topical and biologic options for adult atopic dermatitis.
Signos Wins Clearance for First Over-The-Counter CGM for Weight Management
The combination of the Dexcom Stelo glucose biosensor with an AI platform provides real-time data on how food, exercise, stress, and sleep affect the body.
ACOG Publishes Revised Guidance on Maternal Immunization for COVID-19, Influenza, and RSV
ACOG CEO: “In the face of misinformation and vaccine hesitancy, a strong, evidence-based recommendation...from a trusted clinician can go a long way."
Mediterranean Diet Linked to Reduced Risk of Dementia, Especially in Groups With High Genetic Risk
The protective effect of the diet was strongest in the highest-risk group, those homozygous for the APOE4 gene variant, suggesting that diet may help offset genetic risk.
Investigational Oral IL-23 Receptor Antagonist Improves Skin Clearance in Psoriasis: Daily Dose
Your daily dose of the clinical news you may have missed.
Adults Visiting the ED Are Willing to Receive Missing CDC-Recommended Vaccines, Survey Finds
More than 90% of adults making nonurgent ED visits had missed at least 1 CDC-recommended vaccine but many were willing to catch up on all of them while there.
Countering Vaccine Misinformation in Clinical Practice with Amesh Adalja, MD: Primary Viewpoints Podcast
Infectious disease expert shares strategies for PCPs to counter vaccine myths, navigate policy changes, and build patient trust.
In Adults With Obesity, GLP-1 Receptor Agonists May Reduce Risk for Cancer
GLP-1 use was associated with lower overall cancer risk, with the strongest associations observed for endometrial and ovarian cancers and meningioma.
Upadacitinib Shows Significant Hair Regrowth in Second Phase 3 Trial for Severe Alopecia Areata
AbbVie reports that upadacitinib met primary and secondary endpoints, with up to 55% of patients achieving at least 80% scalp hair coverage at 24 weeks.
Head-To-Head Trial Shows Dynavax’s Z-1018 Rivals Shingrix for Efficacy and Tolerability
Z-1018, which combines a glycoprotein E (gE) antigen and proprietary adjuvant, was evaluated in adults aged 50 to 69 and the 100 µg dose will advance to part 2 of the trial.
Excess Intake of Ultraprocessed Foods Tied to Higher Cardiometabolic Risk: Daily Dose
Obesity and Venous Disease: Risk Factors and Key Diagnostic Challenges
Shagun Bindlish, MD, board member of the American Diabetes Association, discusses challenges to diagnosing and treating venous disease in patients with obesity.
With Medical Societies "Uninvited" From ACIP Vaccine Working Groups, Is There Any Hope for Harmonized Schedules?
William Schaffner, MD, a long-time liaison from the NFID to the ACIP working groups, is concerned about fragmentation of US vaccine recommendations.
Atumelnant for Congenital Adrenal Hyperplasia Agent Granted FDA Orphan Drug Designation
The FDA's ODD award is based on the positive findings from the phase 2 TouCAHn trial, which also support Crinetics' robust phase 3 pivotal clinical trial program for the novel agent.
Vaginal Estradiol Not Linked to Recurrent Ischemic Stroke in Women With Prior Stroke
Vaginal estradiol is often prescribed as first-line therapy for genitourinary syndrome of menopause, making the findings supportive of current clinical practice.
Use of Digital Twin Technology Enabled Significant HbA1c Reduction and Medication Tapering in Primary Care T2D Management
A Cleveland Clinic trial revealed that AI-driven precision treatment significantly reduced HbA1c and body weight, often eliminating need for medications other than metformin.
Mailed FIT Kits Boost CRC Screening at Ages 45–49: Daily Dose
Risk of Major Depressive Disorder Spikes Following a Medical Diagnosis, Endures for Decades: New Data
The risk for MDD is greatest in the first month after diagnosis and the absolute risk remains elevated even 20 years later, making early detection and treatment imperative.
First Oral Penem Antibiotic Now Available in the US for Uncomplicated UTIs
The first oral penem antibiotic, Orlynvah™, has launched in the US, offering a vital treatment option for women with resistant uncomplicated UTIs.
The Weekly Dose: Nutrition Gaps, Tau Pathology in Mood Disorders, RSV Protection, and More
This week’s roundup covers nutrition counseling barriers, tau pathology in mood disorders, RSV protection, AD patient needs, and a new Shingrix syringe.