Novel Combination Treatment is Potent Driver of Beta Cell Proliferation in Type 1 Diabetes Model
In the mouse model of type 1 diabetes, a combined harmine/exendin-4 therapy resulted in an up to 7-fold increase in β cell numbers over 3 months, reported investigators.
Combined SGLT2i and GLP-1 RA Therapy Provides Complementary Cardiorenal Protection, According to Comprehensive Meta-Analysis
Findings from the large meta-analysis provide strong support for use of both classes to reduce CV and renal disease in adults with type 2 diabetes.
Respiratory Virus Vaccine Update: AAFP Board Chair Details ACIP 2024-25 Recommendations
Tochi Iroku-Malize, MD, discusses the ACIP's updated recommendations for immunization against COVID-19, influenza, and RSV.
Roflumilast Cream 0.15% Approved for Treatment of Atopic Dermatitis in People Aged 6 Years and Older
The steroid-free cream was developed for long-term use and has been proven safe in an open-label extension study following successful phase 3 trials.
7 Drugs Approved for Primary Care: Q2 2024
ICYMI: A quick look at 7 key drugs FDA-approved in the second quarter for conditions commonly seen in primary care.
Americans Unaware of Opioid Use Disorder Treatment in Primary Care: Daily Dose
Your daily dose of the clinical news you may have missed.
Remaining Free of Diabetes for at Least 4 Years Improves Long-Term Health in Persons with Impaired Glucose Tolerance
Long-term risk of death decreased by 26% and risk for vascular complications decreased by 40% in persons who remained diabetes-free for 4 years, according to new data.
FDA Issues CRL to Novo Nordisk for Once-Weekly Insulin Icodec
The agency is concerned about manufacturing processes involved in production and about the proposed indication for adults with type 1 diabetes.
FDA Approves Donanemab for Early Symptomatic Alzheimer Disease: Daily Dose
In the Old and Very Old, Statins Appear Safe for Primary CVD Prevention, New Analysis Finds
Continuous statin use among adults aged 75 years and older resulted in a mean relative risk reduction in CVD of 28% without heightened safety concerns, a new study found.
Massachusetts Standing Orders Increase Emergency Contraceptive Access
Following the statewide order in August 2022, emergency contraceptive fills at Massachusetts pharmacies increased by 32% compared with rates in other states.
Chest Pain in a Tween: Seen in the ED
The 11-year-old girl has had a fever up to 102.1°F for 3 days and midsternal nonpleuritic chest pain for 1 day. What tests would you order? Your Dx?
States with Higher COVID-19 Vaccination Rates Saw Reduction in Pediatric Asthma Prevalence
A new study shows that higher vaccination rates were associated with a decrease in the prevalence of parent-reported asthma symptoms in children.
Workplace Sexual Harassment Linked to Higher Risk of Cardiometabolic Diseases: Daily Dose
Prenatal RSV Vaccine Not Associated with Preterm Birth, According to First Real-World Data
Data from a study performed during the first season the shot was available expand on clinical trial evidence and support the safety of RSVpreF, authors wrote.
Weight Loss with Tirzepatide Significantly Greater than with Semaglutide: New Data
Tirzepatide-treated participants were 3 times more likely than those treated with semaglutide to reach weight loss of 15% or greater, the head-to-head study found.
GLP-1RAs Linked to Decreased Risk of Some Obesity-Related Cancers in Patients with T2D
GLP-1RAs were associated with a significantly reduced risk of obesity-associated cancers including gallbladder cancer, pancreatic cancer, and meningioma.
FDA Approves Ensifentrine for Maintenance Treatment of COPD in Adults: Daily Dose
More Than 60% of US Adults Unaware Primary Care Clinicians Can Prescribe Medications for Opioid Use Disorder
Findings from a national survey also showed that Black respondents were most likely to believe they could not receive medications for OUD at a PCP.
Aspirin Still Used for Primary Prevention among Older Americans Without CVD: Daily Dose
