Diabetes

Up to 80% of those with necrobiosis lipoidica have diabetes mellitus; however, this disorder develops in fewer than 1% of people who have diabetes.

Early use of combination therapy to treat type 2 diabetes is shown to limit glucose toxicity and preserve beta-cell function.

Despite best efforts with lifestyle modification and adherence to metformin and glimepiride therapy, this man’s A1C continues to rise. What next?

For many patients with diabetic peripheral neuropathy, severe pain can be controlled to a degree sufficient to improve their quality of life. Here: effective management strategies, including topical agents, oral medications, and nonpharmacological therapies (eg, acupuncture and transcutaneous nerve stimulation).

Blood sugar and HbA1C are very high; how would you treat this patient's hyperglycemia?

Type 2 diabetes mellitus is affecting teenagers at an alarming rate. Lifestyle changes are paramount in an environment of chronic caloric surplus.

Once-weekly exenatide, the recently approved GLP-1 receptor agonist, may help improve treatment adherence and outcomes in patients with type 2 diabetes.

The Outcomes Reduction with Initial Glargine Intervention trial: No elevated risk of cardiovascular disease, cancer when insulin is used early to treat T2DM.

The 2012 ADA/EASD Position Statement prescribes patient-centered care for type 2 diabetes management using lifestyle change, metformin, DPP-4Is, GLP-1 RAs.

This type 2 diabetes office-visit checklist tracks A1c, lipid, and blood pressure goals, and lets you monitor regular labs, exams, and diabetes education.

These burning red patches around the mouth, known as perleche, are aggravated by aging. Learn how to treat it.

New research finds that type 2 diabetes mellitus, once considered a disease of “adult onset,” is highly resistant to treatment in overweight American youths-a group succumbing to the disorder at an alarming rate. Here, a comment on the cultural norms that make choosing health a daily battle.

The elderly patient has had type 2 diabetes for 15 years is now home bound after a stroke. Her HbA1c is 9.6 and she takes only metformin. Review the rest of her laboratory results and propose a management plan.

Would you treat the elevated A1C aggressively-and what would your target level be? Would you consider statins? Dr Shahady invites your insights.

Do you consider an LDL of 100 and a non-HDL of 150 significant? What is your diagnosis? Would you consider medication in addition to recommending lifestyle changes? Answers to these quiz questions here.

A 47-year-old man sees you for a check-up. He complains only of low energy and attributes it to recent weight gain. But, there is much more.

The American College of Physicians (ACP) has recently published its updated guidelines for type 2 diabetes mellitus (T2DM) management. While touted as "new," these guidelines offer no real breakthroughs in understanding. Our blogger offers a perspective; we’d like to hear yours.

Spots on the shins may indicate diabetes.

A 50-year-old African American woman with type 2 diabetes mellitus and hypertension was admitted with constant bilateral knee and thigh pain and swelling of both knees, all of 1 week’s duration. The pain was not relieved with hydrocodone/acetaminophen and had caused weakness and subsequent falls.

Dr Robert Gabbay discusses strategies to improve patient compliance with insulin therapy.

However, persistent, unexplained hypoglycemia can indicate a potentially grave, often treatable, underlying disorder, such as insulinoma, or adrenal or pituitary insufficiency.

How can you determine whether your patient with newly diagnosed diabetes has type I or type II disease?

Adding aliskiren to antihypertension regimens that already include losartan reduced blood protein levels from 19% to 22% in hypertensive type 2 diabetic patients with nephropathy.

A review of 140 trials and 26 observational studies supports metformin as the best first-line treatment for type 2 diabetes in adults, both stand-alone and in combination with other medications. But second-line treatments are still a judgment call.

A variety of effective treatments are available for diabetic peripheral neuropathic pain (DPNP), including topical agents, oral medications, and nondrug approaches. The lidocaine patch 5% is recommended for relatively localized pain.

Are persons with asthma at risk for other proinflammatory disorders? Yes, say researchers from the Mayo Clinic and Olmsted Medical Center in Rochester, Minn, who found that asthma is associated with the development of diabetes mellitus and coronary artery disease. However, there was no association between asthma and rheumatoid arthritis or inflammatory bowel disease.

Since it came onto the market in 1983, glyburide has been one of the most popular sulfonylureas. The American Diabetes Association (ADA) recommends the use of these agents as part of a stepwise approach to treating type 2 diabetes mellitus.