August 12th 2025
Your daily dose of the clinical news you may have missed.
August 11th 2025
FDA accepts priority review of gepotidacin for uncomplicated urogenital gonorrhea, with phase 3 data showing non-inferiority to standard injectable therapy.
July 25th 2025
Nirsevimab lowered the risk of RSV-related illness by over 87% and hospitalizations by 98% in a new study.
July 24th 2025
Vaccination lowered influenza cases by about 33% to 42% in seasonal flu setups with 40% vaccine effectiveness, researchers reported.
July 17th 2025
Merck has launched phase 3 trials for MK-8527, a promising once-monthly HIV prevention pill, aiming to enhance PrEP options globally.
Remdesivir for Severe COVID-19: Expert Guidance on Use in Clinical Practice
Elizabeth Sapey, PhD, discusses how the updated treatment recommendations from the World Health Organization may impact future use of remdesivir.
Remdesivir for Treatment of Severe COVID-19: Expert Reviews Latest Evidence
Elizabeth Sapey, PhD, discusses findings from the SOLIDARITY study and similar research on the efficacy of remdesivir for treatment of severe disease.
Are the Southern Hemisphere's High Influenza Rates a Warning for the North This Year?
Influenza rates were higher in Australia during the April-October season this year than they have been in 5 years. Should we be preparing now?
WHO Recommends Remdesivir for Severe COVID-19: Expert Perspective on Updated Therapeutic Guideline
Elizabeth Sapey, PhD, discusses the updated recommendations and the research that prompted the decision.
Persistent COVID-19 Vaccine Myths Hamper Immunization for Children
Refractory adult misbeliefs about vaccine safety have increased reluctance to vaccinate US children aged 5-11 years, according to an Annenberg Public Policy center survey.
Antivirals Recommended for Influenza Treatment & Chemoprophylaxis: Basics, Notes, Cautions
This influenza antiviral brush-up slide show reminds you of key features of the 4 FDA-recommended medications, at-a-glance.
WHO Guideline Update Recommends Against 2 COVID-19 Monoclonal Treatments
WHO: Evidence is lacking for clinical effectiveness of Xevudy and Regen-Cov against the COVID-19 variants that are currently circulating.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 23, 2022
Data from the CDC on US vaccination and booster shot rates and from the Johns Hopkins COVID-19 interactive map on cases and deaths in the US and worldwide.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 21, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 20, 2022
Phase 3 Trial Now Underway of Investigational mRNA-based Influenza Vaccine
Pfizer announced that the first participants have been dosed in a novel phase 3 efficacy clinical trial of its quadrivalent modified RNA influenza vaccine candidate.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 19, 2022
Study: At-home COVID-19 Tests Less Effective After Omicron Emergence
The performance of 3 commercially available COVID-19 home-testing kits worsened during the emergence of the omicron variant, according to a new cross-sectional study.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 16, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 15, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 13, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 12, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 9, 2022
COVID-19 Bivalent Booster Shot Q&A for Clinicians
Get answers to 7 questions you may have regarding bivalent booster dose vaccination for patients from the US Centers for Disease Control and Prevention.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 8, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 7, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 6, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of September 2, 2022
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of August 31, 2022
FDA Authorizes Pfizer and Moderna Updated COVID-19 Booster Shots
The FDA EUA amendments for updated booster vaccinations are based on clinical studies of the omicron BA.1 variant and preclinical data on the BA.4 and BA.5 variants.
The Future of US Antimicrobial Resistance is in Our Hands and There is Work to Do
Steer clear of antibiotic Rxs whenever possible, says Anne Meneghetti, MD, to help the US get back to pre-COVID levels of antimicrobial stewardship.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of August 30, 2022
Primary Care Can Help Restore US Antibiotic Stewardship, Starting with Flu Shots
Preventing viral infections with vaccination can keep the most vulnerable out of the hospital, reducing the risk of bacterial superinfections.
COVID-19 Update: US Vaccinations, Booster Doses, & Global Data as of August 29, 2022
Superinfection Rate in Hospitalized COVID-19 Patients was Found to be Low
Only 9% of inpatients with COVID-19 had a bacterial superinfection that could be treated with antibiotics which curbed use of broad-spectrum antimicrobials.