August 12th 2025
Your daily dose of the clinical news you may have missed.
August 11th 2025
FDA accepts priority review of gepotidacin for uncomplicated urogenital gonorrhea, with phase 3 data showing non-inferiority to standard injectable therapy.
July 25th 2025
Nirsevimab lowered the risk of RSV-related illness by over 87% and hospitalizations by 98% in a new study.
July 24th 2025
Vaccination lowered influenza cases by about 33% to 42% in seasonal flu setups with 40% vaccine effectiveness, researchers reported.
July 17th 2025
Merck has launched phase 3 trials for MK-8527, a promising once-monthly HIV prevention pill, aiming to enhance PrEP options globally.
Daily Dose: Statin Prescribing in Primary Care
Your daily dose of clinical news you may have missed.
Influenza Update: Hospital Admissions Double During post-Thanksgiving Week
The inpatient flu census doubled after Thanksgiving travel and gatherings and ICU beds are full. More at-a-glance stats on Flu in the USA, here.
Seen in the ED: Elevated LFTs and Anemia in a Young Female Student
She reports cough and persistent escalating fever x2 weeks, headache but no neck stiffness. Tachycardia and mild skin pallor seen on PE. What do the lab tests tell you?
Pfizer-BioNTech Seek EUA for Omicron Booster in Children Aged Under 5 Years
Pfizer and BioNTech submitted an application to the FDA for emergency use authorization of their omicron BA.4/BA.5-adapted bivalent COVID-19 vaccines in children aged 6 months to 4 years.
Tripledemic Virus Spread Could Jeopardize Holiday Season 2022, says CDC Director Walensky
Flu rates are up after the Thanksgiving holiday week, COVID-19 hospitalizations are increasing, and RSV may or may not be on the wane as Christmas approaches.
Daily Dose: Top Factors that Predict Long COVID
Increased Risk of Long COVID Observed in Women, Persons with Elevated BMI
Analysis of an online survey in the UK found women vs men and higher vs lower BMI were associated with greater likelihood of developing long COVID.
Brush up on RSV: Symptoms, Risks, and Treatment
Respiratory syncytial virus is an age-old winter foe that could affect many of your patients this year. Take a minute and scan these facts for a refresher.
Daily Dose: Parent-Pediatrician Vaccine Discussions Lagging?
Parent-Pediatrician Vaccine Discussions are Lagging, National Poll Finds
One in 7 parents have not discussed vaccines with their child's primary clinician during the 2-year pandemic period, according to a CS Mott Children's Hospital poll.
CDC Reports Flu Activity at 10-year High as COVID-19 and RSV Fill Hospital Beds
Overall flu activity is at a 10-year high, according to the CDC's most recent influenza surveillance report, while US hospitals are already overwhelmed.
Investigational Fentanyl Vaccine Could Block the Opioid from the Brain
A vaccine against fentanyl could stop the intense euphoria the drug creates and also block dangerous physiologic responses like respiratory depression, a new study suggests.
Large Analysis of Hospitalized Children with Influenza Supports Early Oseltamivir Treatment
Early oseltamivir use reduced the length of hospitalization and risk for hospital readmission in children hospitalized with influenza, according to new research.
Vaccine Confidence Significantly Eroded During Pandemic, Across Demographics
Confidence in vaccines is lower post-pandemic across all demographic groups and is not limited to traditional "anti-vaxxers," say authors of a new study.
Pediatric RSV Vaccines: Why Are We Still Waiting?
I have admitted infants to the hospital every winter for 40 years, yet I still don't have good answers for anxious parents watching their child struggling to breathe.
7 RSV Myths and Facts: Prepare for the New Wave of Misinformation
RSV is back for the 2022-23 respiratory virus season and is unfamiliar to many. Click through this quick collection of myths already in circulation to prepare.
Maternal RSV Vaccine Prevents Infection in Infants, Pfizer Announces
Topline phase 3 trial data showed 81.8% efficacy for the maternal vaccine against severe RSV-related illness in infants from birth through first 90 days of life.
Adult RSV Vaxx Gets EMA Nod: Can USA be Far Behind?
The GSK RSV vaccine candidate has received favorable international regulatory attention which may be an auspicious sign for the US.
Daily Dose: Recombinant Zoster Vaccine Provides 10 Years of Protection
Daily Dose: High-dose Flu Vaccine Consistently More Effective vs Standard-dose
Recombinant Zoster Vaccine Protection Durable at 10 Years, New Study Finds
Efficacy of the RZV vaccine against herpes zoster infection remained >80% in a long-term follow-up study representing 10 years since initial immunization.
Fluticasone Exhalation Delivery System Reduced Exacerbations, Need for Antibiotics in Patients with Chronic Sinusitis
IDWeek 2022: New data show a greater than 60% reduction in acute exacerbations and need for antibiotics in patients with CS who used fluticasone propionate nasal spray.
COVID-19 Vaccine Status Update: Adults, Bivalent Boosters, Kids, & Teens
The overall US COVID-19 vaccination picture has both bright spots and dark areas. Get a quick look at details from the most recent KFF Vaccine Monitor survey.
High-dose Influenza Vaccine Consistently More Effective vs Standard-dose in Older Adults: Meta-analysis
The high-dose influenza vaccines provided greater relative vaccine effectiveness/efficacy vs standard dose in a cohort of more than 45 million.
Primary Care is the Likely "Home" for Long COVID Care: A Conversation with AAFP Board Chair Sterling Ransone, Jr, MD
AAFP Board Chair Ransone points to recent data that show two-thirds of long COVID patients are already treated in primary care settings.
We Can't Predict a COVID-19 Surge, But We Can Prepare Patients for It: AAFP Board Chair Dr Sterling Ransone, Jr
It is clear that COVID-19 comes in waves, but it's too soon in the life of the virus to predict patterns, Ransone says. Strategy? Get shots in arms.
Will This be the Year of the Twindemic? AAFP Board Chair Ransone Thinks Out Loud with Patient Care
About half of American adults plan not to get a flu shot this year; everyone is tired of COVID talk and prevention; but flu is brewing in the southern hemisphere, Ransone says.
The Daily Dose: Adult RSV Vaccine
Your daily dose of clinical news from Patient Care Online.
GSK Announces Positive Pivotal Phase 3 Data for Adult RSV Vaccine Candidate
The investigational respiratory syncytial virus vaccine had an overall efficacy of 82.6% against RSV-LRTD, 94.6% against severe disease, and 94.1% in adults with comorbidities.
COVID-19 Vaccines, Boosters, Prior Infection Significantly Reduce Risks, but Immunity Wanes
A large cohort study confirms the observed efficacy of initial and follow-up COVID-19 vaccination and prior infection against infection, hospitalization, and death.