June 10th 2025
The novel triple fixed-dose combination of telmisartan, amlodipine and indapamide, is the first of its kind approved for initial treatment of hypertension.
Podcast: Did Heart Disease Kill Whitney Houston?
April 18th 2012The Los Angeles county coroner’s office recently ruled that singer Whitney Houston drowned in her hotel bathtub but that other factors contributed to her demise. Did the 48-year-old have preexisting cardiovascular disease? Did cocaine abuse trigger a deadly cardiac event? Drs Payal Kohli and Christopher Cannon put the autopsy results and the pop star’s final moments in context.
Eating Red Meat Now Associated With Cardiovascular and Cancer Mortality
April 7th 2012It’s a known fact that regular consumption of red meat increases the risk of many chronic diseases-including diabetes, coronary heart disease, and cancer. Now, data from 2 large, long-term studies link daily consumption of red meat with death from cardiovascular disease and cancer. Drs Kohli and Cannon discuss what to tell your patients.
Novel Treatment Lowers LDL Cholesterol by Up to 80%
April 4th 2012There’s a new way to lower LDL cholesterol levels-by approximately 60% to 80%. Studies unveiled at the 2012 ACC meeting found that an injectable monoclonal antibody, when added to statin therapy cuts LDL cholesterol levels far in excess of what can be achieved with statin therapy alone. Drs Christopher Cannon and Payal Kohli discuss.
Statin Therapy and Oral Antidiabetic Drugs: On Adherence and Initiation
March 24th 2012Patients with type 2 diabetes should be receiving statin therapy, but many patients who would benefit from these agents are not taking them-and not reaching target lipid levels. A recent study shows that timing of statin initiation can make a difference. Here to put the issue into perspective are Drs Christopher Cannon and Payal Kohli.
Statins and the New FDA Warnings: What Does It All Mean for Your Patients?
March 3rd 2012Statins have been shown to significantly reduce the risk of heart attacks, heart disease and death. But this week, the FDA decided that the package inserts of the various statins must now include a warning that these agents may raise blood glucose levels and that they can cause memory loss. Here to put this issue into perspective are Drs Christopher Cannon and Payal Kohli.
Regular Exercise in Middle Age Can Build Heart Muscle
April 8th 2011Exercising at least 4 times a week can increase left ventricular mass and preserve elasticity, thereby reducing the risk of diastolic heart failure. Researchers from Texas presented their study results at the American College of Cardiology’s 60th Annual Scientific Session.
Shorter Antiplatelet Regimen Sufficient After Stenting
April 8th 2011What is the optimal duration for antiplatelet therapy after placement of drug-eluting stents? Initial results of the EXCELLENT study show that 6 months of antiplatelet therapy is as effective as the 12-month regimen recommended by current guidelines.
Chronic Heart Failure Outcomes Not Improved by NT-proBNP-Guided Treatment
April 6th 2011A Danish study found no clinical benefit from using NT-proBNP (b-type natriuretic peptide) to identify and monitor high-risk patients with chronic heart failure, according to research from the NorthStar study presented at the American College of Cardiology’s 60th Annual Scientific Session in New Orleans.
CABG Bests Medical Therapy in Ischemic Heart Failure
April 6th 2011Compared with medical therapy alone, coronary artery bypass grafting (CABG) significantly reduced cardiovascular deaths and the composite end point of all-cause deaths and cardiovascular-related hospitalizations, reported investigators from the Surgical Treatment of Ischemic Heart Failure (STICH) trial. However, the effect of the two management strategies on overall survival in patients with ischemic heart failure was similar.
What’s the Evidence Behind Updated ACC/AHA Guidelines on Unstable Angina/Non-STEMI?
April 5th 2011Recently, the American College of Cardiology (ACC) and the American Heart Association (AHA) released a focused update to the 2007 guidelines for the management of patients with unstable angina (UA)/non-ST-elevation myocardial infarction (non-STEMI).
Heart Failure With Preserved Ejection Fraction: Lessons From Three Cases
April 4th 2011The panel presented three challenging cases of heart failure with preserved ejection fraction (HFPEF) (see Update on Diastolic Heart Failure). In an innovative twist, the panel solicited feedback from a standing-room-only audience through SmartPhone technology-attendees voted for their favored diagnostic approach, therapy, or final diagnosis, with voting results instantly integrated into the presenter’s Powerpoint display.
Update on Diastolic Heart Failure-and Implications for Primary Care
April 4th 2011Diastolic heart failure (or HFPEF-heart failure with preserved ejection fraction) is characterized by inadequate myocardial relaxation and diastolic filling ("stiff ventricle"), with heart failure signs and symptoms despite normal ejection fraction. The most common cause is long-standing hypertension.
Elevated C-Reactive Protein Predicts Myocardial Deterioration
April 4th 2011Systemic inflammation has been identified as a risk factor for the development of heart failure in population studies. In the 5-year prospective MESA study, researchers from Johns Hopkins Hospital in Baltimore recorded a baseline nonspecific marker of systemic inflammation, C-reactive protein (CRP).
Serial ProBNP Measurement: A Cutting-Edge Approach to Systolic Heart Failure
April 4th 2011Researchers from Massachusetts General Hospital in Boston presented results from the PROTECT (ProBNP Outpatient Tailored Chronic Heart Failure) study. NT-proBNP (b-type natriuretic peptide) is a biomarker released from myocardial tissue in response to high levels of wall stretch and has been studied as a marker for decompensated systolic heart failure.
Myth or Evidence-Based Reality:Do Patent Foramen Ovales Lead to Cryptogenic Strokes?
March 10th 2011On December 18, 2005, Ariel Sharon, Prime Minister of Israel, experienced the sudden onset of aphasia. Despite being overweight, he had none of the traditional risk factors for cerebrovascular disease-hypertension, history of smoking, diabetes, or elevated cholesterol levels.