Transitioning to the Real-World: Expert Experiences with Nasal Epinephrine Spray

EP: 1.Understanding Anaphylaxis: The Signs, Symptoms, and Burdens

EP: 2.Epinephrine First: The Proven First-Line Treatment for Anaphylaxis

EP: 3.Bridging the Barriers: What is Preventing Patients From Using Epinephrine

EP: 4.An Opportunity for Innovation: Rethinking Unmet Needs in Epinephrine Administration

EP: 5.Nasal Epinephrine Spray: Review of Clinical Trial Results

EP: 6.Immediate Impact: Nasal Epinephrine Spray After Allergen Challenge

EP: 7.Safety Solidified: Results of Oral Food Challenge Trials With Nasal Epinephrine Spray

EP: 8.A Fit for Many: Storage, Shelf Life, and Ideal Patients

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EP: 9.Transitioning to the Real-World: Expert Experiences with Nasal Epinephrine Spray

Clinical Case Studies and Implementation Strategies

Two real-world case studies demonstrate Neffy's effectiveness in clinical practice. A 15-year-old with tree nut allergy accidentally ingested cashew and walnut, developing chest tightness, cough, and facial swelling 30 minutes post-exposure. She self-administered Neffy within 4 minutes of symptom onset, experiencing rapid improvement within 5 minutes and complete resolution within one hour, with only mild, self-limited side effects including temporary tachycardia and shakiness.

The second case involved an 8-year-old undergoing milk oral immunotherapy who developed repetitive coughing and vomiting after his routine dose. His mother administered 2mg Neffy followed by antihistamine, resulting in significant cough improvement within 2 minutes and complete symptom resolution within 15 minutes. Both patients reported they would choose Neffy again over available auto-injectors, indicating high patient satisfaction and confidence.

Shared decision-making represents the optimal approach for epinephrine device selection, ensuring patients receive the option that maximizes their confidence and likelihood of prompt administration. Healthcare providers should present all available options while emphasizing that the best epinephrine device is the one patients know how to use, are willing to use, and will carry consistently. Neffy particularly benefits patients with needle aversion, confidence issues with auto-injectors, portability concerns, or cost considerations related to frequent device replacement needs.