A Fit for Many: Storage, Shelf Life, and Ideal Patients

EP: 1.Understanding Anaphylaxis: The Signs, Symptoms, and Burdens

EP: 2.Epinephrine First: The Proven First-Line Treatment for Anaphylaxis

EP: 3.Bridging the Barriers: What is Preventing Patients From Using Epinephrine

EP: 4.An Opportunity for Innovation: Rethinking Unmet Needs in Epinephrine Administration

EP: 5.Nasal Epinephrine Spray: Review of Clinical Trial Results

EP: 6.Immediate Impact: Nasal Epinephrine Spray After Allergen Challenge

EP: 7.Safety Solidified: Results of Oral Food Challenge Trials With Nasal Epinephrine Spray

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EP: 8.A Fit for Many: Storage, Shelf Life, and Ideal Patients

EP: 9.Transitioning to the Real-World: Expert Experiences with Nasal Epinephrine Spray

Safety Profile and Temperature Stability Advantages

Neffy demonstrated an excellent safety profile in clinical trials involving 700+ patients and over 1,000 administered doses, with no serious adverse events reported. Common side effects were infrequent, mild, and resolved quickly, including nasal discomfort, headache, rhinorrhea, throat irritation, and class-effect symptoms like jitteriness and tremor. The intranasal route eliminates needle-related complications such as injection site reactions, infections, and accidental needle injuries.

Temperature stability represents a significant advantage over traditional auto-injectors. While both device types should ideally be stored at room temperature, Neffy tolerates short excursions of 3-4 days at temperatures up to 122°F, making it suitable for outdoor activities and sports. This enhanced temperature tolerance addresses concerns about epinephrine degradation in hot conditions that frequently affect athletes and outdoor enthusiasts.