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SGLT2 Inhibitors & GLP-1 Receptor Agonists: Differences, Similarities, Patient Selection
SGLT2 inhibitors and GLP-1 receptor agonists are changing the type 2 diabetes treatment paradigm. We summarize the most recent data here and offer guidance on patient benefits.
Newer classes of diabetes drugs have brought a paradigm shift in diabetes management. Several large cardiovascular outcome trials suggest that SGLT2 inhibitors and GLP1 receptor agonists both decrease cardiovascular risk, and some studies suggest a role for renoprotection.
Recent research raises several important questions: Is there a difference between SGLT2 inhibitors and GLP1 agonists for cardiovascular and renal protection? If so, which one is better, and for which patients? Evidence and guidance follow.
Oral PCSK9 Inhibitor Enlicitide Meets All End Points in Phase 3 Hypercholesterolemia Trial
September 2nd 2025At week 24, patients receiving once-daily enlicitide demonstrated statistically significant and clinically meaningful reductions in low-density lipoprotein cholesterol compared with placebo.
