The 2 FDA-approved COVID-19 vaccines are similarly effective but also very different in a number of ways that will affect distribution.
The US Food and Drug Administration has approved for emergency use 2 vaccines against the coronavirus disease 2019 (COVID-19), one from Pfizer-BioNTech (December 11, 2020) and the other from Moderna (December 18, 2020).
The vaccines are very similar in terms of efficacy and both require a priming dose followed by a booster a few weeks later. But there are vast differences in aspects like cold chain storage and even minimum purchase amount required that are already impacting who likely will receive which vaccine.
The short slide show below summarizes a comparison of features published on the web site STAT.
No Rx Required for COVID-19 Vaccination But ACIP Calls for Better Informed Consent Process
September 22nd 2025The ACIP on September 19 narrowly voted against requiring a prescription to get the shot but urged more detailed discussion of vaccine risks during shared decision making conversations.