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Diabetes Complication: Diabetic Vasculopathy
Cutaneous manifestations develop inapproximately 30% of persons withdiabetes. Premature atherosclerosisis a common complication of thedisease and can cause peripheral infarction,ulceration, and necrosis.
Cutaneous manifestations develop inapproximately 30% of persons withdiabetes. Premature atherosclerosisis a common complication of thedisease and can cause peripheral infarction,ulceration, and necrosis.As seen here on the finger of a64-year-old man who has a 25-yearhistory of diabetes mellitus, ulcerationsecondary to insensible traumacan arise from diabetic neuropathy.Healing of such a lesion may befurther complicated by vascular insufficiencyrelated to the disease.The pathogenic mechanism of vascular disease in diabetes is not clearly understood. Earlydiagnosis and tight glucose control afford the best opportunity to delay disease progression.This patient was referred to a vascular surgeon for evaluation and treatment.(Case and photograph courtesy of Drs Charles E. Crutchfield III, Eric J. Lewis, and Humberto Gallego.)
Sotagliflozin in Patients with Type 1 Diabetes and CKD to be Discussed at October FDA AdComm Meeting
October 14th 2024Lexicon's sotagliflozin is on the October 31 docket for discussion by the FDA's Endocrinologic and Metabolic Drugs Advisory Committee; PDUFA goal date remains set for December 20.
