History of present illness. An elderly man was washing dishes when he became very dizzy and almost fainted. He was a poor historian and there was a language barrier requiring an interpreter, but he seemed to endorse symptoms of both vertigo and near-syncope as well as "a funny feeling in his chest" during the episode, which lasted about 5-10 minutes. He denies pain, fever, cough, headache, or other symptoms and feels fine now.
Vital signs & physical examination. Vital signs were normal although the systolic BP was significantly different—by >20 mm Hg—between arms. The rest of the physical exam, including the HINTS exam, Romberg, gait, and orthostatic measures were all normal.
Initial Diagnostic Testing
Oral PCSK9 Inhibitor Enlicitide Meets All End Points in Phase 3 Hypercholesterolemia Trial
September 2nd 2025At week 24, patients receiving once-daily enlicitide demonstrated statistically significant and clinically meaningful reductions in low-density lipoprotein cholesterol compared with placebo.