Ruxolitinib Cream Demonstrates Long-Term Disease Control in Atopic Dermatitis

Leon H Kircik, MD

As-needed treatment with 1.5% ruxolitinib cream provided sustained disease control in patients with mild to moderate atopic dermatitis (AD), according to findings from the TRuE-AD1 and TRuE-AD2 studies. Among patients who continued treatment for 52 weeks (n=428), rates of clear or almost clear skin improved from 67.1% at week 8 to 77.8% at week 52. Additionally, no days of itch were reported by 36.2% of patients at week 52, compared to 32.7% at week 8. Sleep disturbance-free nights increased from 71.8% to 74.5%, and the proportion of patients with no AD-related quality of life (QoL) burden rose from 57.1% to 59.8%. By the study’s end, 30.0% of participants met all 4 disease control criteria.

The findings, released by Incyte, were presented at the 2025 American Academy of Dermatology Meeting, being held March 7-11, in Orlando, FL.

The randomized controlled trials included patients aged 12 years and older with AD for at least 2 years, an Investigator’s Global Assessment (IGA) score of 2 or 3, and 3%–20% affected body surface area. Participants initially received twice-daily 0.75% or 1.5% ruxolitinib cream or vehicle for 8 weeks, followed by 44 weeks of as-needed treatment with ruxolitinib cream in a long-term safety evaluation period. Disease control assessments incorporated IGA scores, the Patient-Oriented Eczema Measure for itch and sleep disturbance, and the Dermatology Life Quality Index or children’s DLQI.

These findings underscore the efficacy of 1.5% ruxolitinib cream in achieving and maintaining symptom relief and skin clearance while improving QoL in adolescents and adults with mild to moderate AD.

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Source: Kircik L, Blauvelt A, Szepietowski C, et al. Ruxolitinib Cream Demonstrated Long-Term Disease Control and Quality of Life Benefits in Adults and Adolescents With Mild to Moderate Atopic Dermatitis. Abstract presented at the 2025 American Academy of Dermatology Meeting; March 7-11, 2025. Orlando, FL.