"It is very important to understand the correlation between insulin resistance and diabetes and insulin resistance and obesity," said Shagun Bindlish, MD, medical director of One Medical in Dublin, California, in a recent interview with Patient Care Online.
Dr Bindlish, joined by Dr Peminda K. Cabandugama, director of Digital Obesity at the Cleveland Clinic, sat down with Patient Care® to discuss what they consider are the most important elements of the relationship between obesity and type 2 diabetes (T2D), including the role of insulin resistance, understanding the connections between insulin resistance, T2D, and obesity, and why a change in lifestyle should be top of mind for clinicians when seeing patients with T2D and obesity. More of their conversation follows.
Lilly’s Oral GLP-1 Orforglipron Meets End Points in Phase 3 Obesity and Diabetes Trial
August 26th 2025Patients taking orforglipron achieved significant weight loss, hemoglobin A1c reduction, and cardiometabolic benefits in the phase 3 ATTAIN-2 study, supporting upcoming global regulatory submissions.