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Matters of the Heart: Simultaneous Pneumoperitoneum and Acute Inferior Wall Myocardial Infarction
A 70-year-old man with a history of peptic ulcer disease presented with a 1-dayhistory of epigastric pain. Abdominal examination revealed mild epigastrictenderness. A pneumoperitoneum was discovered on a chest film (A), and aleft decubitus chest film (B) confirmed this diagnosis.
A 70-year-old man with a history of peptic ulcer disease presented with a 1-dayhistory of epigastric pain. Abdominal examination revealed mild epigastrictenderness. A pneumoperitoneum was discovered on a chest film (A), and aleft decubitus chest film (B) confirmed this diagnosis.An ECG demonstrated signs of acute inferior wall myocardial infarction(MI). In addition to the standard management of acute MI, this patient underwentemergency surgical repair of the perforated duodenal ulcer, from whichhe recovered fully.Epigastric pain could be the presenting symptom of inferior wall MI. However,a coexisting pneumoperitoneum should be suspected in a patient with apeptic ulcer.
Roche, Alnylam Advance Zilebesiran Into Phase 3 CV Outcomes Trial for Resistant Hypertension
September 9th 2025Zilebesiran’s twice-yearly dosing and sustained BP reductions could offer a new therapeutic approach for adults with resistant hypertension and high CV risk who are uncontrolled on current SOC regimens.
Oral PCSK9 Inhibitor Enlicitide Meets All End Points in Phase 3 Hypercholesterolemia Trial
September 2nd 2025At week 24, patients receiving once-daily enlicitide demonstrated statistically significant and clinically meaningful reductions in low-density lipoprotein cholesterol compared with placebo.
