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Lichen Amyloidosis
This is the most common form of amyloid deposition in the skin. It is not associated with the systemic disease, but is solely a cutaneous malady.
A 57-year-old man presents for evaluation of an intensely itchy eruption involving both forelegs. He is ostensibly in good health and denies medication use.
Key point: This is a distinctly unique presentation consisting of close-set, monomophous, red-brown papules with slight scale, located on the shins. The diagnosis is almost always lichen amyloidosis, a form of primary cutaneous amyloid. Itching is typically severe.
Treatment: There is no specific therapy. Oral antihistamines may be sufficient to relieve itching. UVA and UVB phototherapy may also help alleviate itching, although the papules will persist.
Note: This is the most common form of amyloid deposition in the skin. It is NOT associated with systemic disease, but is solely a cutaneous malady. Lichen amyloid is more common in late middle age (50 to 60 years) and in men.
Atopic Dermatitis: The Pipeline and Clinical Approaches That Could Transform the Standard of Care
September 24th 2025Patient Care tapped the rich trove of research and expert perspectives from the Revolutionizing Atopic Dermatitis 2025 conference to create a snapshot of the AD care of the future.
