This serious symptom constellation is seen in a 21-year-old man. Is it familiar to you?
A 21-year-old male with a history of chronic aphthous mouth ulcers is seen with a diffuse severe erosive dermatitis accompanied by arthritis; he also has genitourinary symptoms suggestive of urethritis and ocular signs associated with vitritis and retinal vasculitis.

Taken together the elements of this presentation point to which of the following?
Kymera's Oral STAT6 Degrader KT-621 Shows Biologic-Like Activity in Early Atopic Dermatitis Trial
December 8th 2025KT-621 achieved deep STAT6 degradation and strong 4-week EASI and itch reductions, offering a potential new oral option for moderate–severe AD and other Th2 inflammation-driven disease.