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Benign Seborrheic Keratosis
Biopsies of this large variegated pigmented plaque ruled out lentigo maligna melanoma and gigantic seborrheic keratosis.
A 72-year-old man complained about an asymptomatic, gradually expanding “spot” on his forehead.
Key point: Physical examination revealed a large variegated pigmented plaque with a palpable surface. Regional adenopathy was absent. The differential diagnosis consisted of a lentigo maligna melanoma and gigantic seborrheic keratosis. Multiple small biopsies were obtained from different sections of the lesion, and all demonstrated benign seborrheic keratosis.
Treatment: The patient was reassured and declined any treatment for cosmetic reasons.
Note: Pre-biopsy dermoscopy was used to attempt to establish the diagnosis. All portions of the lesion did, indeed, demonstrate characteristics consistent with the biopsy-proven diagnosis. While dermatoscopic examination is a very useful technique, biopsy was still indicated to completely assuage the patient’s concerns.
Atopic Dermatitis: The Pipeline and Clinical Approaches That Could Transform the Standard of Care
September 24th 2025Patient Care tapped the rich trove of research and expert perspectives from the Revolutionizing Atopic Dermatitis 2025 conference to create a snapshot of the AD care of the future.
