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Atypical Nevus
This pigmented macule clearly stands out against a bland background of fair-complected skin. This is known as the “ugly duckling” sign. Such lesions should always be viewed with suspicion and a biopsy is generally indicated.
A 44-year-old woman sought medical attention because of the new appearance of a “dark” but asymptomatic lesion located on the right flank.
Key point: This pigmented macule clearly stands out against a bland background of fair-complected skin. This is what is known as the “ugly duckling” sign. Such lesions should always be viewed with suspicion.
Treatment: Conservative excision revealed this lesion to be a moderately atypical nevus. No further treatment was entertained.
Note: A biopsy is more often than not indicated for all such lesions. Smaller lesions are best excised with a narrow margin (2 mm). Wide repeated excision would subsequently be performed if severe atypia or overt melanoma were found on histopathology.
Lebrikizumab Demonstrates Efficacy, Safety in Patients With Skin of Color With AD
June 11th 2025RAD 2025. Lebrikizumab improved skin clearance, itch, and pigmentation in patients with skin of color and atopic dermatitis, with strong safety data through 24 weeks, according to late-breaking data.
