the dramatic elevation of aminotransferases may be the result of medication toxicity, acute viral hepatitis, or ischemic injury to the liver. Your assessment?
A 68-year-old man with alcoholic cirrhosis presents with worsening confusion. Lab test results are notable for an AST of 3600 U/L and an ALT 4200 U/L. His alkaline phosphatase level is within normal limits and his total bilirubin is 3.1 mg/dL. His INR is 1.4.
Which of the following is the most likely cause of his presentation?
a. Cholangiocarcinoma
b. Acute hepatitis A
c. Alcoholic hepatitis
d. Acetaminophen toxicity
FDA Approves Updated Indication Statement for Upadacitinib in Inflammatory Bowel Disease Treatment
October 14th 2025FDA approves updated indication for upadacitinib in ulcerative colitis and Crohn disease treatment, allowing use after one systemic therapy when TNF blockers are clinically inadvisable.