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AHA Abstract Wrap-up: Smoking, Cessation, and TV Behavior
Three abstracts from AHA 2018 shed light on long-term impacts of smoking (and cessation) on CV disease and how CV disease influences sedentary behavior.
Three abstracts published in the current issue of Circulation and in association with the American Heart Association Scientific Sessions 2018 provide updates on how smoking cessation and activity levels affect cardiovascular risk and mortality.In the first study, Meredith Duncan and colleagues found that while significant reductions in CVD occur within 5 years of quitting smoking it may take over 15 years to reach the risk of the general non-smoking population.In the second study, Christoph Saely and colleagues found that current but not past smoking strongly increased mortality risk in angiographied coronary patients with and without type 2 diabetes.And, in the third study, Lucas Helal and fellow researchers found an independent link between sedentary behavior and cardiovascular risk factors.Thumb through the slides below for details on these studies and take-home points for clinical practice.
Roche, Alnylam Advance Zilebesiran Into Phase 3 CV Outcomes Trial for Resistant Hypertension
September 9th 2025Zilebesiran’s twice-yearly dosing and sustained BP reductions could offer a new therapeutic approach for adults with resistant hypertension and high CV risk who are uncontrolled on current SOC regimens.
Oral PCSK9 Inhibitor Enlicitide Meets All End Points in Phase 3 Hypercholesterolemia Trial
September 2nd 2025At week 24, patients receiving once-daily enlicitide demonstrated statistically significant and clinically meaningful reductions in low-density lipoprotein cholesterol compared with placebo.
