Adult-onset psoriasis is uncommon without a precipitating factor. In this patient’s case, an oral beta-blocker precipitated the psoriasis.
A 58-year-old man complained of the recent onset of a widespread, mildly pruritic rash. He was in good health except for about a 1-year history of symptomatic supraventricular arrhythmia.
Key point: Physical examination revealed a disseminated rash consisting of indurated, erythematous plaques variably covered by silver scales. A biopsy was read as psoriasis.
Treatment: The patient responded well to topical application of a mid-potency corticosteroid combined with narrow-band UVB phototherapy.
Note: Adult-onset psoriasis is uncommon without a precipitating factor. This patient was given an oral beta-blocker as management for his arrhythmia. Medications may precipitate otherwise typical psoriasis among those who are predisposed to this disorder.
Roche, Alnylam Advance Zilebesiran Into Phase 3 CV Outcomes Trial for Resistant Hypertension
September 9th 2025Zilebesiran’s twice-yearly dosing and sustained BP reductions could offer a new therapeutic approach for adults with resistant hypertension and high CV risk who are uncontrolled on current SOC regimens.