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Acquired Cystic Kidney Disease and Renal Cell Carcinoma
A 45-year-old man complained of blood in his urine. The patient had a 7-year history of chronic renal failure secondary to hypertension; he had undergone hemodialysis for the past 5 years.
A 45-year-old man complained of blood in his urine. The patient had a 7-year history of chronic renal failure secondary to hypertension; he had undergone hemodialysis for the past 5 years.
The physical examination was unremarkable. White blood cell and platelet counts were normal; hemoglobin level was 7 g/dL; hematocrit, 20%; blood urea nitrogen level, 50 mg/dL; and creatinine level, 6 mg/dL. Other laboratory findings were within normal limits.
Both a CT scan (A) and an MRI (B) of the abdomen showed multiple bilateral renal cysts. A solid component was seen in the middle of a cyst in the left kidney (white arrows).
Multiple small retroperitoneal lymph nodes (black arrows) also were noted.
Drs Hesham M. Taha, Japinder Singh, Gamil Kostandy, and David Dosik of New York Methodist Hospital, Brooklyn, made the diagnosis of acquired cystic kidney disease (ACKD) complicated by renal cell carcinoma. ACKD is usually asymptomatic and has been described in patients with end-stage renal disease.1 Renal cell carcinoma is the most serious of the complications associated with ACKD.2-4
In one study, renal cell carcinoma developed in 3.85% of patients with ACKD who were undergoing dialysis. This incidence is significant-ly higher than that in the general population.5
The pathogenesis of renal cell carcinoma is unclear. It may occur in a multistep sequence, advancing from cyst to adenoma to adenocarcinoma. This process may not be stopped even if the uremia is corrected.6
CT is the diagnostic method of choice for ACKD.7 Periodic CT studies of all patients undergoing hemodialysis is costly and not warranted; appropriate candidates for evaluation include white men who have been undergoing hemodialysis for more than 3 years and patients with back pain; genitourinary bleeding; and sonographic findings of solid renal mass, hemorrhagic renal cyst, or adenopathy.8 This patient underwent a nephrectomy; immunotherapy was given postoperatively.
REFERENCES:1. Dunnill MS, Millard PR, Oliver D. Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance of haemodialysis. J Clin Pathol. 1977;39:868-877.
2. Truong LD, Krishnan B, Cao JT, et al. Renal neoplasm in acquired cystic kidney disease. Am J Kidney Dis. 1995;26:1-12.
3. Bretan PN Jr, Busch MP, Hricak H, Williams RD. Chronic renal failure: a significant risk factor in the development of acquired renal cysts and renal cell carcinoma. Case reports and review of the literature. Cancer. 1986;57:1871-1879.
4. Hughson MD, Hennigar GR, McManus JF. Atypical cysts, acquired renal cystic disease, and renal cell tumors in end stage dialysis kidneys. Lab Invest. 1980;42:475-480.
5. Sasagawa I, Terasawa Y, Imai K, et al. Acquired cystic disease of the kidney and renal carcinoma in haemodialysis patients: ultrasonographic evaluation. Br J Urol. 1992;70:236-239.
6. Grantham JJ. Acquired cystic kidney disease [clinical conference]. Kidney Int. 1991;40:143-152.
7. Bosniak MA. The small (less than or equal to 3.0 cm) renal parenchymal tumor: detection, diagnosis, and controversies. Radiology. 1991;179:302-317.
8. Garcia de la Oliva T, Valdes P, Ramos B. Renal cell carcinoma in patients with acquired cystic renal disease. A case report. Ren Fail. 1993;15:649-651.
