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Abdominal Aortic Aneurysm: Screen Older Male Smokers, Says USPSTF
The United States Preventive Services Task Force narrows recommendations for populations that warrant screening. Guideline revisions are based on a new evidence review.
The overall incidence of abdominal aortic aneurysms (AAA) is low; however, the rate of associated morbidity and mortality after rupture is very high, thus close screening remains an important lifesaving intervention. When determining optimal candidates for screening, however, important issues that must be considered are the cost of screening, cost of surgery, the potentially associated morbidity, and the cost of surveillance.
The newest guidelines on screening1 (still awaiting finalization), which were recently released by the United States Preventive Services Task Force (USPSTF), include some noteworthy changes to previous versions. These revisiosn are based on results of an evidence review published in January 2014 in The Annals of Internal Medicine that suggested a reduction in AAA-related mortality (without a significant reduction in all-cause mortality) with one-time screening of asymptomatic men aged 65 years and older, at up to 15-year follow-up. The clinical risk factors for AAA that emerged from this analysis were male sex, older age, smoking, and family history. Of interest, black or Hispanic race and diabetes were associated with a relatively lower risk of having an AAA.
These recommendations, along with others from contemporary societies,1-3 are summarized in the Table.
Comparison of the recommendations show significant variability among expert societies on AAA screening, especially in women. Therefore, the decision to screen each patient should be individualized based on a careful consideration of risk factors, such as family history, age, sex, and smoking history. However, the information in the Table serves as an outline that can be used to identify those groups that may and may not benefit from screening.
Table. Reccomendations for Screening for Abdominal Aortic Aneurysm
References:
- Guirguis-Blake JM, Beil TL, Senger CA, Whitlock EP. Ultrasonography screening for abdominal aortic aneurysms: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2014 Jan 28. doi: 10.7326/M13-1844.
- 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with thoracic aortic disease. Circulation. 2010;121:e266-e369.
- Kent KC, Zwolak RM, Jaff MR, et al. Screening for abdominal aortic aneurysm: a consensus statement. J Vasc Surg. 2004;39:267-269.
Roche, Alnylam Advance Zilebesiran Into Phase 3 CV Outcomes Trial for Resistant Hypertension
September 9th 2025Zilebesiran’s twice-yearly dosing and sustained BP reductions could offer a new therapeutic approach for adults with resistant hypertension and high CV risk who are uncontrolled on current SOC regimens.
Oral PCSK9 Inhibitor Enlicitide Meets All End Points in Phase 3 Hypercholesterolemia Trial
September 2nd 2025At week 24, patients receiving once-daily enlicitide demonstrated statistically significant and clinically meaningful reductions in low-density lipoprotein cholesterol compared with placebo.
