Spinal Cord Stimulators for Chronic Pain May do More Harm than Good, Suggests Real-world Study
Large study comparing spinal cord stimulators to conventional medical management found a lack of clinical benefit for most patients and possible harm to some.
Decreased Dementia Risk Associated with Increased Daily Step Count
A daily step count of as few as 3800 was associated with a 25% reduced risk of incident dementia in a cohort of 78 000 adults; the optimal count was fewer than 10 000.
Increased Risk of Stroke, CV Event after Herpes Zoster Persists Beyond 12 Years
Study participants who had HZ were at 30% greater sustained risk of stroke and CHD vs those who had not had HZ in this large multicohort prospective study.
US Preterm Birth Rate Reaches 15-year High, Racial Disparities are "Unacceptable"
Racial disparities in maternal, prenatal, and infant care are "stark and unacceptable," say authors of the March of Dimes 2022 Report Card.
Parent-Pediatrician Vaccine Discussions are Lagging, National Poll Finds
One in 7 parents have not discussed vaccines with their child's primary clinician during the 2-year pandemic period, according to a CS Mott Children's Hospital poll.
Allopurinol May Help Prevent First ACS Event in Patients with Gout
Allopurinol exposures of 100 mg or more than 100 mg were associated with lower odds of first-ever ACS with some differences between sexes, a new study reports.
Doubling Levonorgestrel Dose Fails to Prevent Pregnancy in Women with Obesity
The "Plan B" emergency contraceptive at 2 times the normal dose was not more effective in study participants with BMI >30.
Daily Dose: HDL Cholesterol May No Longer be So "Good"
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Survey Finds Physician Morale Sinking as Staffing, Administrative Challenges Mount
Physician morale continues to sink as staffing challenges and administrative burdens increase with primary care seeing "devastating effects."
HDL Cholesterol May Not Universally Predict Risk for CHD, May No Longer be So "Good"
The analysis of a large biracial cohort found low levels of HDL-C linked to increased CHD risk in White but not Black adults and high HDL-C was not protective in either group.
Daily Dose: High-risk Patients with Atrial Fibrillation Not Prescribed Anticoagulation
Study: Wearable Activity Trackers Have Potential to Support Decision Making, Clinical Care
Wearable activity trackers could potentially support clinical care for patients with pulmonary arterial hypertension, according to a new study.
CDC Reports Flu Activity at 10-year High as COVID-19 and RSV Fill Hospital Beds
Overall flu activity is at a 10-year high, according to the CDC's most recent influenza surveillance report, while US hospitals are already overwhelmed.
Daily Dose: Over-the-Counter Naloxone
FDA Approves Teplizumab, First Drug Indicated to Prevent Type 1 Diabetes
Teplizumab, an anti-CD3 monoclonal antibody, delayed the median onset of stage 3 T1D by approximately 2 years compared to placebo in a pivotal clinical trial.
The Promise of Precision Medicine for Obesity: It Should be Simple
Ordering an obesity phenotype should be as simple and routine as ordering an HbA1c or a lipid panel, says obesity expert Andres Acosta, MD, PhD.
As Many as 1 in 3 High-risk Patients with Atrial Fibrillation are Not Prescribed Anticoagulation
The low rate of stroke prevention with oral anticoagulation in patients with atrial fibrillation is cause for significant concern, say investigators.
Certain Over-the-Counter Naloxone Products “May be Approvable,” According to Preliminary FDA Data
A preliminary assessment from the FDA suggests certain naloxone products may be safely used without a prescription to prevent opioid overdose deaths.
Opioids for Pain Management: Guideline Topline for Primary Care
A guideline topline of the CDC's 2022 clinical guidance for prescribing opioids for pain in adults.
Obesity Phenotype-targeted Treatment Choice Nearly Doubled Weight Loss in Clinical Trials: Investigator Interview
Obesity physician-scientist Andres Acosta, MD, PhD, reviews findings from recent studies he led that suggest true potential for phenotype-focused weight loss intervention.